{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:49:07Z","timestamp":1792468147617,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              Late-gadolinium\u2013enhanced (LGE) cardiac MRI (CMR) is a powerful method for characterizing myocardial infarction (MI), but the requisite gadolinium infusion is estimated to be contraindicated in \u224820% of patients with MI because of end-stage chronic kidney disease. The purpose of this study is to investigate whether T\n              <jats:sub>1<\/jats:sub>\n              CMR obtained without contrast agents at 3 T could be an alternative to LGE CMR for characterizing chronic MIs using a canine model of MI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Canines (n=29) underwent CMR at 7 days (acute MI [AMI]) and 4 months (chronic MI [CMI]) after MI. Infarct location, size, and transmurality measured by using native T\n              <jats:sub>1<\/jats:sub>\n              maps and LGE images at 1.5 T and 3 T were compared. Resolution of edema between AMI and CMI was examined with T\n              <jats:sub>2<\/jats:sub>\n              maps. T\n              <jats:sub>1<\/jats:sub>\n              maps overestimated infarct size and transmurality relative to LGE images in AMI (\n              <jats:italic>P<\/jats:italic>\n              =0.016 and\n              <jats:italic>P<\/jats:italic>\n              =0.007, respectively), which was not observed in CMI (\n              <jats:italic>P<\/jats:italic>\n              =0.49 and\n              <jats:italic>P<\/jats:italic>\n              =0.81, respectively) at 3 T. T\n              <jats:sub>1<\/jats:sub>\n              maps underestimated infarct size and transmurality relative to LGE images in AMI and CMI (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) at 1.5 T. Relative to the remote territories, T\n              <jats:sub>1<\/jats:sub>\n              of the infarcted myocardium was increased in CMI and AMI (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), and T\n              <jats:sub>2<\/jats:sub>\n              of the infarcted myocardium was increased in AMI (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) but not in CMI (\n              <jats:italic>P<\/jats:italic>\n              &gt;0.20) at both field strengths. Histology showed extensive replacement fibrosis within the CMI territories. CMI detection sensitivity and specificity of T\n              <jats:sub>1<\/jats:sub>\n              CMR at 3 T were 95% and 97%, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Native T\n              <jats:sub>1<\/jats:sub>\n              maps at 3 T can determine the location, size, and transmurality of CMI with high diagnostic accuracy. Patient studies are necessary for clinical translation.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.113.001541","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T01:49:32Z","timestamp":1396057772000},"page":"471-481","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Determination of Location, Size, and Transmurality of Chronic Myocardial Infarction Without Exogenous Contrast Media by Using Cardiac Magnetic Resonance Imaging at 3 T"],"prefix":"10.1161","volume":"7","author":[{"given":"Avinash","family":"Kali","sequence":"first","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Cokic","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.Q.","family":"Tang","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Jung","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Sharif","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Marb\u00e1n","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Dharmakumar","sequence":"additional","affiliation":[{"name":"From the Biomedical Imaging Research Institute, Department of Biomedical Sciences (A.K., I.C., R.L.Q.T., H.-J.Y., B.S., D.L., R.D.) and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (E.M., D.L., D. S. B., R.D.); Department of Bioengineering (A.K., H.-J.Y.) and Department of Medicine, David Geffen School of Medicine (D. S. B., R.D.), University of California, Los Angeles, CA; and Department of Radiology, Northwestern University, Chicago, IL (A.K., R.L.Q.T., D.L., R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1161"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.059"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.122622"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.09.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.19.1992"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-200038581"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21767"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4801.100351"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-120025231"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-120022267"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21272"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182631c37"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22716"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2503080253"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes145"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.865352"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.12.002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-69"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-15"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-42"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199103000-00006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303052"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.112.976738"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.019"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-200053623"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-35"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.020"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-59"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.112.000133"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60195-0"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002863"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.070"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.111.963421"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110228"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000127428.10985.c6"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk062"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060601"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322030334"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-37"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451061590"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.020"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20605"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00889.2002"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.545863"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.111.1201"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24867"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330206"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22053"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.113.001541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:40:19Z","timestamp":1715568019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.113.001541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1161\/CIRCIMAGING.113.001541"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.113.001541","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"2013-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}