{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:01:22Z","timestamp":1789167682039,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              Ascending aortic dissection and rupture remain a life-threatening complication in patients with Marfan syndrome. The extracellular matrix provides strength and elastic recoil to the aortic wall, thereby preventing radial expansion. We have previously shown that ascending aortic aneurysm formation in Marfan mice (\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              ) is associated with decreased aortic wall elastogenesis and increased elastin breakdown. In this study, we test the feasibility of quantifying aortic wall elastin content using MRI with a gadolinium-based elastin-specific magnetic resonance contrast agent in\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              mice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Ascending aorta elastin content was measured in 32-week-old\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              mice and wild-type (n=9 and n=10, respectively) using 7-T MRI with a T1 mapping sequence. Significantly lower enhancement (ie, lower R1 values, where R1=1\/T1) was detected post\u2013elastin-specific magnetic resonance contrast agent in\n              <jats:italic>Fbn1<\/jats:italic>\n              <jats:sup>C1039G\/+<\/jats:sup>\n              compared with wild-type ascending aortas (1.15\u00b10.07 versus 1.36\u00b10.05;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). Post\u2013elastin-specific magnetic resonance contrast agent R1 values correlated with ascending aortic wall gadolinium content directly measured by inductively coupled mass spectroscopy (\n              <jats:italic>P<\/jats:italic>\n              =0.006).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Herein, we demonstrate that MRI with elastin-specific magnetic resonance contrast agent accurately measures elastin bound gadolinium within the aortic wall and detects a decrease in aortic wall elastin in Marfan mice compared with wild-type controls. This approach has translational potential for noninvasively assessing aneurysm tissue changes and risk, as well as monitoring elastin content in response to therapeutic interventions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.114.001658","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T06:27:07Z","timestamp":1399703227000},"page":"690-696","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Assessment of Elastin Deficit in a Marfan Mouse Aneurysm Model Using an Elastin-Specific Magnetic Resonance Imaging Contrast Agent"],"prefix":"10.1161","volume":"7","author":[{"given":"Homare","family":"Okamura","sequence":"first","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Pisani","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Dalal","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Emrich","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Dake","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Arakawa","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Onthank","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Cesati","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Robinson","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Milanesi","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyula","family":"Kotek","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Smit","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Connolly","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Adachi","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"McConnell","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Fischbein","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiothoracic Surgery (H.O., A.R.D., F.E., B.A.D., M.A., M.P.F.), Radiology (L.J.P.), and Pathology (A.J.C.), Stanford University, CA; Department of Cardiovascular Surgery, Jichi Medical University, Saitama Medical Center, Saitama, Japan (H.O., M.A., H.A.); Lantheus Medical Imaging, North Billerica, MA (D.C.O., R.R.C., S.P.R.); Agilent Technologies, Yarnton, Oxford, United Kingdom (M.M.); Departments of Radiology (G.K.) and Medical Informatics and Radiology (H.S.), Erasmus..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"Centers for Disease Control and Prevention National Center for Health Statistics. Compressed Mortality File 1999\u20132010. CDC WONDER On-line Database. http:\/\/wonder.cdc.gov\/cmf-icd10.html. Accessed on June 2 2014."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000155243.70456.f4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00065-9"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000126921.29919.51"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.1.37"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1697-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.03.019"},{"key":"e_1_3_4_10_2","first-page":"15","article-title":"Future imaging techniques in aortic pathologies and clinical implications.","volume":"54","author":"Clough R","year":"2013","unstructured":"Clough R, Taylor P. Future imaging techniques in aortic pathologies and clinical implications. J Cardiovasc Surg (Torino). 2013;54(1 suppl 1):15\u201319.","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.109.895607"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2310"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198809001-00059"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/153303460700600207"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23807"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24251"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420641"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.253740"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.690982"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-S1-O4"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8144"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022749"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.068163"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.114.001658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:21:23Z","timestamp":1715566883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.114.001658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1161\/CIRCIMAGING.114.001658"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.114.001658","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"2013-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}