{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:27:28Z","timestamp":1790339248626,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>To prospectively evaluate whether short-term high-intensity (interval) training (HI(I)T) induces detectable morphological cardiac changes in previously untrained men in cardiovascular magnetic resonance imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Eighty-four untrained volunteers were randomly assigned to a HI(I)T group (n=42; 44.1\u00b14.7 years) or an inactive control group (n=42; 42.3\u00b15.6 years). HI(I)T focused on interval runs (intensity: 95%\u2013105% of individually calculated heart rate at the anaerobic threshold). Before and after 16 weeks, all subjects underwent physiological examination, stepwise treadmill test with blood lactate analysis, and contrast-enhanced cardiovascular magnetic resonance imaging (cine, tagging, and delayed enhancement). Indexed left ventricular (LV) and right ventricular (RV) volume (LV, 77.1\u00b18.5\u201383.9\u00b18.6; RV, 80.5\u00b18.5\u201386.6\u00b18.1) and mass (LV, 58.2\u00b16.4\u201363.4\u00b18.1; RV, 14.8\u00b11.7\u201316.1\u00b12.1) significantly increased with HI(I)T. Changes in LV and RV morphological parameters with HI(I)T were highly correlated with an increase in maximal aerobic capacity (VO\n              <jats:sub>2max<\/jats:sub>\n              ) and a decrease in blood lactate concentration at the anaerobic threshold. Mean LV and RV remodeling index of HI(I)T group did not alter with training (0.76 \u00b10.09 and 0.24\u00b10.10 g\/mL, respectively [\n              <jats:italic>P<\/jats:italic>\n              =0.97 and\n              <jats:italic>P<\/jats:italic>\n              =0.72]), indicating balanced cardiac adaptation. Myocardial circumferential strain decreased after HI(I)T within all 6 basal segments (anteroseptal,\n              <jats:italic>P<\/jats:italic>\n              =0.01 and anterolateral,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). There was no late gadolinium enhancement in any of the participants before or post HI(I)T.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Sixteen weeks of HI(I)T lead to measurable changes in cardiac atrial and ventricular morphology and function in previously untrained men. This correlates with improvements in parameters of endurance capacity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01406730.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.114.002566","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T01:12:21Z","timestamp":1429060341000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Myocardial Adaptation to High-Intensity (Interval) Training in Previously Untrained Men With a Longitudinal Cardiovascular Magnetic Resonance Imaging Study (Running Study and Heart Trial)"],"prefix":"10.1161","volume":"8","author":[{"given":"Michael","family":"Scharf","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schmid","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kemmler","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"von Stengel","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias S.","family":"May","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wuest","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Achenbach","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Uder","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Lell","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (M.S., A.S., M.S.M., W.W., M.U., M.M.L.), Medical Physics (W.K., S.v.S.), and Cardiology (S.A.), Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"Running USA Web site. 2013 State of the sport - part III: U.S. race trends. http:\/\/www.runningusa.org\/state-of-sport-2013-part-III?returnTo=annual-reports. Accessed April 30 2014."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/OAJSM.S68701"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-100423"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972915"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.336"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02478-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90228-7"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2007.00706.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.069401"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-11"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511081118"},{"key":"e_1_3_4_13_2","first-page":"960","article-title":"Evidence based exercise - clinical benefits of high intensity interval training.","volume":"41","author":"Shiraev T","year":"2012","unstructured":"Shiraev T, Barclay G. Evidence based exercise - clinical benefits of high intensity interval training. Aust Fam Physician. 2012;41:960\u2013962.","journal-title":"Aust Fam Physician"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12873"},{"key":"e_1_3_4_15_2","first-page":"312","article-title":"Cardiovascular damage resulting from chronic excessive endurance exercise.","volume":"109","author":"Patil HR","year":"2012","unstructured":"Patil HR, O\u2019Keefe JH, Lavie CJ, Magalski A, Vogel RA, McCullough PA. Cardiovascular damage resulting from chronic excessive endurance exercise. Mo Med. 2012;109:312\u2013321.","journal-title":"Mo Med"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr397"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3318"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.10.020"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-65"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/10976649909080829"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.7.666"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90940-Z"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10092377"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613562"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.022"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CAIM.0000013160.79903.19"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2007.038158"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92243-9"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-38"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-58"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110909082"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.039"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.325115098"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-120013299"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2014\u2013093895"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.647461"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93072-U"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.101063"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.114.002566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:20:30Z","timestamp":1715566830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.114.002566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1161\/CIRCIMAGING.114.002566"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.114.002566","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"2014-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e002566"}}