{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:10:30Z","timestamp":1789441830324,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Endothelial dysfunction present in patients with peripheral artery disease may be better understood by measuring the temporal dynamics of blood flow and oxygen saturation during reactive hyperemia than by conventional static measurements.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Perfusion, Intravascular Venous Oxygen saturation, and T\n              <jats:sub>2<\/jats:sub>\n              * (PIVOT), a recently developed MRI technique, was used to measure the response to an ischemia\u2013reperfusion paradigm in 96 patients with peripheral artery disease of varying severity and 10 healthy controls. Perfusion, venous oxygen saturation SvO\n              <jats:sub>2<\/jats:sub>\n              , and T\n              <jats:sub>2<\/jats:sub>\n              * were each quantified in the calf at 2-s temporal resolution, yielding a dynamic time course for each variable. Compared with healthy controls, patients had a blunted and delayed hyperemic response. Moreover, patients with lower ankle-brachial index had (1) a more delayed reactive hyperemia response time, manifesting as an increase in time to peak perfusion in the gastrocnemius, soleus, and peroneus muscles, and in the anterior compartment, (2) an increase in the time to peak T\n              <jats:sub>2<\/jats:sub>\n              * measured in the soleus muscle, and (3) a prolongation of the posterior tibial vein SvO\n              <jats:sub>2<\/jats:sub>\n              washout time. Intrasession and intersession repeatability were also assessed. Results indicated that time to peak perfusion and time to peak T\n              <jats:sub>2<\/jats:sub>\n              * were the most reliable extracted time course metrics.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Perfusion, dynamic SvO\n              <jats:sub>2<\/jats:sub>\n              , and T\n              <jats:sub>2<\/jats:sub>\n              * response times after induced ischemia are highly correlated with peripheral artery disease severity. Combined imaging of peripheral microvascular blood flow and dynamics of oxygen saturation with Perfusion, intravascular SvO\n              <jats:sub>2<\/jats:sub>\n              , and T\n              <jats:sub>2<\/jats:sub>\n              * may be a useful tool to investigate the pathophysiology of peripheral artery disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.114.002673","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T01:12:21Z","timestamp":1429060341000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Multiparametric Assessment of Vascular Function in Peripheral Artery Disease"],"prefix":"10.1161","volume":"8","author":[{"given":"Erin K.","family":"Englund","sequence":"first","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Langham","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly J.","family":"Fanning","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix W.","family":"Wehrli","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Emile R.","family":"Mohler","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Floyd","sequence":"additional","affiliation":[{"name":"From the Department of Bioengineering (E.K.E.), Department of Radiology (M.C.L., F.W.W.), Department of Biostatistics &amp; Epidemiology (S.J.R.), Department of Medicine (E.R.M.), University of Pennsylvania, Philadelphia; and Department of Anesthesiology, Stony Brook University, NY (T.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.3.510"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.18.2.185"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.009"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128520.37674.EF"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80066-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.3026"},{"key":"e_1_3_4_9_2","first-page":"21","article-title":"Collateral circulation in health and disease.","volume":"74","author":"Beatty JO","year":"1957","unstructured":"Beatty JO, Payne JH, Rudy N, Winsor T. 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