{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T03:56:28Z","timestamp":1769572588741,"version":"3.49.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              Cardiac\n              <jats:sup>123<\/jats:sup>\n              I-metaiodobenzylguanidine (\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG) imaging improves prognostication in patients with left ventricular (LV) dysfunction. Whether\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG can identify optimal candidates for implantable cardiac defibrillator (ICD) placement is unclear. We examined whether\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG enhances risk assessment and identifies patients with enhanced survival with ICD in a patient cohort with reduced LV function who were candidates for ICD implantation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We identified 777 patients (66 sites, 12 countries) without ICD at the time of enrollment in Adreview Myocardial Imaging for Risk Evaluation in Heart Failure (ADMIRE-HF) and index\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG study. Patients completed prescribed study protocol and follow-up. Heart-to-mediastinum (H\/M) ratio was determined from\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG results. Survival modeling used a Cox proportional hazards mixed-effects model, including a propensity score, to adjust for nonrandomized ICD implantation after\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG. All-cause death occurred in 75 patients (9.6%), and 196 (25%) patients had ICD implantation on follow-up. After adjusting for multiple factors, although the H\/M ratio added incremental prognostic value and enhanced reclassification, neither H\/M results, BNP levels, nor left ventricular ejection fraction interacted with ICD use in the survival model, indicating that these variables did not identify patients with enhanced survival with ICD implantation. Nonetheless, H\/M results did identify the number of lives saved by ICD use per 100 treated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              We found that although\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG imaging enhances the risk stratification of patients with left ventricular dysfunction who are ICD candidates\n              <jats:sup\/>\n              , it does not identify which patients may have improved survival with ICD placement. However,\n              <jats:sup>123<\/jats:sup>\n              I-\n              <jats:italic>m<\/jats:italic>\n              IBG identifies the absolute benefit gained with ICD use, thus may play a role in optimizing the cost-effectiveness of this intervention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifiers: NCT00126425 and NCT00126438.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.114.003110","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T04:53:50Z","timestamp":1450155230000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Predicting Risk Versus Predicting Potential Survival Benefit Using\n            <sup>123<\/sup>\n            I-\n            <i>m<\/i>\n            IBG Imaging in Patients With Systolic Dysfunction Eligible for Implantable Cardiac Defibrillator Implantation"],"prefix":"10.1161","volume":"8","author":[{"given":"Rory","family":"Hachamovitch","sequence":"first","affiliation":[{"name":"From the Cardiovascular Imaging Section, Department of Cardiovascular Medicine Heart and Vascular Institute (R.H., V.M., M.D.C.), Department of Quantitative Health Science (B.N.), and Department of Nuclear Medicine, Imaging Institute (M.D.C.), Cleveland Clinic, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Nutter","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Imaging Section, Department of Cardiovascular Medicine Heart and Vascular Institute (R.H., V.M., M.D.C.), Department of Quantitative Health Science (B.N.), and Department of Nuclear Medicine, Imaging Institute (M.D.C.), Cleveland Clinic, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venu","family":"Menon","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Imaging Section, Department of Cardiovascular Medicine Heart and Vascular Institute (R.H., V.M., M.D.C.), Department of Quantitative Health Science (B.N.), and Department of Nuclear Medicine, Imaging Institute (M.D.C.), Cleveland Clinic, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel D.","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Imaging Section, Department of Cardiovascular Medicine Heart and Vascular Institute (R.H., V.M., M.D.C.), Department of Quantitative Health Science (B.N.), and Department of Nuclear Medicine, Imaging Institute (M.D.C.), Cleveland Clinic, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-4-200708210-00007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.7.809"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.04.033"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959544"},{"key":"e_1_3_3_7_2","first-page":"917","article-title":"Prognostic value of MIBG imaging in idiopathic dilated cardiomyopathy.","volume":"40","author":"Merlet P","year":"1999","unstructured":"Merlet P, Benvenuti C, Moyse D, Pouillart F, Dubois-Rand\u00e9 JL, Duval AM, Loisance D, Castaigne A, Syrota A. 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