{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:35:59Z","timestamp":1780569359861,"version":"3.54.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Late gadolinium-enhanced cardiovascular magnetic resonance imaging overestimates infarct size and underestimates recovery of dysfunctional segments acutely post ST-segment\u2013elevation myocardial infarction. We assessed whether cardiovascular magnetic resonance imaging\u2013derived segmental myocardial strain and markers of myocardial injury could improve the accuracy of late gadolinium-enhancement in predicting functional recovery after ST-segment\u2013elevation myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 164 ST-segment\u2013elevation myocardial infarction patients underwent acute (median 3 days) and follow-up (median 9.4 months) cardiovascular magnetic resonance imaging. Wall-motion scoring, feature tracking\u2013derived circumferential strain (\n              <jats:italic>Ecc<\/jats:italic>\n              ), segmental area of late gadolinium-enhancement (SEE), microvascular obstruction, intramyocardial hemorrhage, and salvage index (MSI) were assessed in 2624 segments. We used logistic regression analysis to identify markers that predict segmental recovery. At acute CMR 32% of segments were dysfunctional, and at follow-up CMR 19% were dysfunctional. Segmental function at acute imaging and odds ratio (OR) for functional recovery decreased with increasing SEE, although 33% of dysfunctional segments with SEE 76% to 100% improved. SEE was a strong predictor of functional improvement and normalization (area under the curve [AUC], 0.840 [95% confidence interval {CI}, 0.814\u20130.867]; OR, 0.97 [95% CI, 0.97\u20130.98] per +1% SEE for improvement and AUC, 0.887 [95% CI, 0.865\u20130.909]; OR, 0.95 [95% CI, 0.94\u20130.96] per +1% SEE for normalization). Its predictive accuracy for improvement, as assessed by areas under the receiver operator curves, was similar to that of MSI (AUC, 0.840 [95% CI, 0.809\u20130.872]; OR, 1.03 [95% CI, 1.02\u20131.03] per +1% MSI for improvement and AUC, 0.862 [0.832\u20130.891]; OR, 1.04 [95% CI, 1.03\u20131.04] per +1% SEE for normalization) and\n              <jats:italic>Ecc<\/jats:italic>\n              (AUC, 0.834 [95% CI, 0.807\u20130.862]; OR, 1.05 [95% CI, 1.03\u20131.07] per +1% MSI for improvement and AUC, 0.844 [95% CI, 0.818\u20130.871]; OR, 1.07 [95% CI, 1.05\u20131.10] per +1% SEE for normalization), and for normalization was greater than the other predictors. MSI and\n              <jats:italic>Ecc<\/jats:italic>\n              remained as significant after adjustment for SEE but provided no significant increase in predictive accuracy for improvement and normalization compared with SEE alone. MSI had similar predictive accuracy to SEE for functional recovery but was not assessable in 25% of patients. Microvascular obstruction provided no incremental predictive accuracy above SEE.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              This multicenter study confirms that SEE is a strong predictor of functional improvement post ST-segment\u2013elevation myocardial infarction, but recovery occurs in a substantial proportion of dysfunctional segments with SEE &gt;75%. Feature tracking\u2013derived\n              <jats:italic>Ecc<\/jats:italic>\n              and MSI provide minimal incremental benefit to SEE in predicting segmental recovery.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isrctn.com\">http:\/\/www.isrctn.com<\/jats:ext-link>\n              . Unique identifier: ISRCTN70913605.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.115.003457","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T02:53:28Z","timestamp":1465527208000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Relationship of Myocardial Strain and Markers of Myocardial Injury to Predict Segmental Recovery After Acute ST-Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"9","author":[{"given":"Jamal N.","family":"Khan","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheraz A.","family":"Nazir","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anvesha","family":"Singh","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Shetye","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence Y.","family":"Lai","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Peebles","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry P.","family":"McCann","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Cardiovascular BRU, Glenfield Hospital, United Kingdom (J.N.K., S.A.N., A.Singh, A.Shetye, F.Y.L., G.P.M.); Department of Cardiology, University Hospital Southampton NHS Trust, United Kingdom (C.P.); Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, United Kingdom (J.W.); and The Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, United Kingdom ..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300513"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01968-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.096798"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00835-0"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.039"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000027818.15792.1e"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-007-0133-7"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1081\/JCMR-120025233"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.02.079"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3137-6"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12726"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090660"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.963421"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110228"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.210906"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2715-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-58"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.11.006"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-7-53"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.02.002"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.099"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-38"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1007-1"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/696983"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.1.1.30"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/10976640600945465"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.5.651"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.01.022"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.070"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.115.003457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:42:59Z","timestamp":1715568179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.115.003457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1161\/CIRCIMAGING.115.003457"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.115.003457","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2015-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003457"}}