{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:41:03Z","timestamp":1791276063837,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Hybrid positron emission tomography and magnetic resonance allows the advantages of magnetic resonance in tissue characterizing the myocardium to be combined with the unique metabolic insights of positron emission tomography. We hypothesized that the area of reduced myocardial glucose uptake would closely match the area at risk delineated by T2 mapping in ST-segment\u2013elevation myocardial infarction patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Hybrid positron emission tomography and magnetic resonance using\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose (FDG) for glucose uptake was performed in 21 ST-segment\u2013elevation myocardial infarction patients at a median of 5 days. Follow-up scans were performed in a subset of patients 12 months later. The area of reduced FDG uptake was significantly larger than the infarct size quantified by late gadolinium enhancement (37.2\u00b111.6% versus 22.3\u00b111.7%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and closely matched the area at risk by T2 mapping (37.2\u00b111.6% versus 36.3\u00b112.2%;\n              <jats:italic>P<\/jats:italic>\n              =0.10, R=0.98, bias 0.9\u00b14.4%). On the follow-up scans, the area of reduced FDG uptake was significantly smaller in size when compared with the acute scans (19.5 [6.3%\u201331.8%] versus 44.0 [21.3%\u201355.3%];\n              <jats:italic>P<\/jats:italic>\n              =0.002) and closely correlated with the areas of late gadolinium enhancement (R 0.98) with a small bias of 2.0\u00b15.6%. An FDG uptake of \u226545% on the acute scans could predict viable myocardium on the follow-up scan. Both transmural extent of late gadolinium enhancement and FDG uptake on the acute scan performed equally well to predict segmental wall motion recovery.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Hybrid positron emission tomography and magnetic resonance in the reperfused ST-segment\u2013elevation myocardial infarction patients showed reduced myocardial glucose uptake within the area at risk and closely matched the area at risk delineated by T2 mapping. FDG uptake, as well as transmural extent of late gadolinium enhancement, acutely can identify viable myocardial segments.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.115.003900","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T04:13:29Z","timestamp":1456805609000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Quantifying the Area at Risk in Reperfused ST-Segment\u2013Elevation Myocardial Infarction Patients Using Hybrid Cardiac Positron Emission Tomography\u2013Magnetic Resonance Imaging"],"prefix":"10.1161","volume":"9","author":[{"given":"Heerajnarain","family":"Bulluck","sequence":"first","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"White","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Casson","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"O\u2019Meara","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Newton","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); The National Institute of Health Research, University College London Hospitals Biomedical Research Centre, UK (H.B., S.K.W., A.S., J.C.M., D.M.Y., D.J.H.); Independent Researcher (S.G.C.); UCL Institute of Nuclear Medicine, University College London Hospital, UK (C.O., S.M.Y.W., A.G., L.M.); London School Hygiene and Tropical Medicine, London,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nicholas","sequence":"additional","affiliation":[{"name":"From the The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK (H.B., S.K.W., G.M.F., A.N., D.M.Y., D.J.H.); 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