{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:08:23Z","timestamp":1768266503498,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS \u2265300 Agatston units. Among 268 10-mm coronary segments, near-infrared spectroscopy images were analyzed for LRP, defined as a bright yellow block on the near-infrared spectroscopy block chemogram. Lipid burden was assessed as the lipid core burden index (LCBI), and large LRP were defined as a maximum LCBI in 4 mm \u2265400. Vessel plaque volume was measured by quantitative intravascular ultrasound. Vessel-level CACS significantly correlated with plaque volume by intravascular ultrasound (\n              <jats:italic>r<\/jats:italic>\n              =0.69;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) but not with LCBI by near-infrared spectroscopy (\n              <jats:italic>r<\/jats:italic>\n              =0.24;\n              <jats:italic>P<\/jats:italic>\n              =0.07). Despite a high CACS, no LRP was detected in 8 (40.0%) subjects. Large LRP having a maximum LCBI in 4 mm \u2265400 were infrequent, found in only 5 (25.0%) of 20 subjects and in only 5 (1.9%) of 268 10-mm coronary segments analyzed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Among individuals with a CACS \u2265300 Agatston units mostly on statins, CACS correlated with total plaque volume but not LCBI. This observation may have implications on coronary risk among individuals with a high CACS considering that it is coronary LRP, rather than calcification, that underlies the majority of acute coronary events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.117.006282","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:10:24Z","timestamp":1507248624000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Multimodality Intracoronary Imaging With Near-Infrared Spectroscopy and Intravascular Ultrasound in Asymptomatic Individuals With High Calcium Scores"],"prefix":"10.1161","volume":"10","author":[{"given":"Ryan D.","family":"Madder","sequence":"first","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacie","family":"VanOosterhout","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Klungle","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbey","family":"Mulder","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Elmore","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Decker","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Langholz","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Boyden","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Muller","sequence":"additional","affiliation":[{"name":"From the Frederik Meijer Heart and Vascular Institute, Spectrum Health, Grand Rapids, MI (R.D.M., S.V., D.K., A.M., M.E., J.M.D., D.L., T.F.B., J.P.); and Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA (J.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.210"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072100"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.461"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361802"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1701"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.8.2157"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00443-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.8.1052"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.05.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.04.012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306849"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25754"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01175-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.09.021"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.9624"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.06.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306118"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.576"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.097"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.086"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev340"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.998"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.036"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.058"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.117.006282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:14:58Z","timestamp":1715566498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.117.006282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1161\/CIRCIMAGING.117.006282"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.117.006282","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"2017-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006282"}}