{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:59:59Z","timestamp":1788753599952,"version":"build-2803163510"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Little is known on the mechanism of acute ischemic mitral regurgitation (IMR) caused by sudden-onset left ventricular dysfunction in acute myocardial infarction (MI). We sought to investigate the mitral valve (MV) complex geometry in acute IMR in comparison with chronic IMR by 2-dimensional and 3-dimensional transthoracic echocardiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Forty-four first-onset acute MI and 36 previous MI with \u2265moderate IMR were examined by 2-dimensional\/3-dimensional transthoracic echocardiography. MV morphology was quantitatively analyzed and compared between the 2 groups. Left ventricular end-diastolic volume and left ventricular end-systolic volume were significantly smaller in acute IMR than in chronic IMR (40.8 [33.1\u201348.3] versus 88.8 [66.5\u2013108.8] mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001, 17.8 [17.0\u201330.1] versus 49.5 [34.2\u201373.7] mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). MV tenting volume and annular area were significantly smaller in acute IMR compared with chronic IMR (0.98 [0.66\u20131.68] versus 1.88 [1.16\u20132.65] cm\n              <jats:sup>3<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.008, 5.17 [4.80\u20135.86] versus 5.81 [5.47\u20138.22] cm\n              <jats:sup>2<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.008). Leaflet surface area was significantly smaller in acute IMR than in chronic IMR (5.78 [5.16\u20136.32] versus 7.56 [6.89\u201311.32] cm\n              <jats:sup>2<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The ratio of MV leaflet surface area and MV annular area was significantly smaller in acute IMR than in chronic IMR (1.08 [1.01\u20131.14] versus 1.28 [1.24\u20131.37];\n              <jats:italic>P<\/jats:italic>\n              =0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Sudden-onset left ventricular dysfunction in acute MI may cause loss of coaptation of the MV even with a relatively mild degree of valve tethering. Compared with previously studied chronic IMR, a smaller leaflet area without leaflet adaptation and a larger hemodynamic burden at the acute onset of MI could result in clinically significant IMR despite relatively small leaflet tethering.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.117.007028","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T09:16:58Z","timestamp":1523006218000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Acute Versus Chronic Ischemic Mitral Regurgitation"],"prefix":"10.1161","volume":"11","author":[{"given":"Shun","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehiro","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshisato","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1759"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.004841"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.5.2167"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01134-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.78"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.12.1400"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826e1058"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-12-46"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.048"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.05.023"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.06.014"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.749440"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.846782"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.092"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.117.007028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:43:59Z","timestamp":1715568239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.117.007028"}},"subtitle":["An Echocardiographic Study of Anatomy and Physiology"],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1161\/CIRCIMAGING.117.007028"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.117.007028","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"2017-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007028"}}