{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:26:57Z","timestamp":1771475217879,"version":"3.50.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Optimal healing of the myocardium after myocardial infarction (MI) requires a suitable degree of inflammation and its timely resolution, together with a well-orchestrated deposition and degradation of ECM (extracellular matrix) proteins.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              MI and SHAM-operated animals were imaged at 3, 7, 14, and 21 days with 3T magnetic resonance imaging using a\n              <jats:sup>19<\/jats:sup>\n              F\/\n              <jats:sup>1<\/jats:sup>\n              H surface coil. Mice were injected with\n              <jats:sup>19<\/jats:sup>\n              F-perfluorocarbon nanoparticles to study inflammatory cell recruitment, and with a gadolinium-based elastin-binding contrast agent to evaluate elastin content.\n              <jats:sup>19<\/jats:sup>\n              F magnetic resonance imaging signal colocalized with infarction areas, as confirmed by late gadolinium enhancement, and was highest 7 days post-MI, correlating with macrophage content (MAC-3 immunohistochemistry; \u03c1=0.89,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n              <jats:sup>19<\/jats:sup>\n              F quantification with in vivo (magnetic resonance imaging) and ex vivo nuclear magnetic resonance spectroscopy correlated linearly (\u03c1=0.58,\n              <jats:italic>P<\/jats:italic>\n              =0.020). T\n              <jats:sub>1<\/jats:sub>\n              mapping after gadolinium-based elastin-binding contrast agent injection showed increased relaxation rate (R\n              <jats:sub>1<\/jats:sub>\n              ) in the infarcted regions and was significantly higher at 21 days compared with 7 days post-MI (R\n              <jats:sub>1<\/jats:sub>\n              [s\n              <jats:sup>\u22121<\/jats:sup>\n              ]: 21 days=2.8 [interquartile range, 2.69\u20133.30] versus 7 days=2.3 [interquartile range, 2.12\u20132.5],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05), which agreed with an increased tropoelastin content (\u03c1=0.89,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). The predictive value of each contrast agent for beneficial remodeling was evaluated in a longitudinal proof-of-principle study. Neither R\n              <jats:sub>1<\/jats:sub>\n              nor\n              <jats:sup>19<\/jats:sup>\n              F at day 7 were significant predictors for beneficial remodeling (\n              <jats:italic>P<\/jats:italic>\n              =0.68;\n              <jats:italic>P<\/jats:italic>\n              =0.062). However, the combination of both measurements (R\n              <jats:sub>1<\/jats:sub>\n              &lt;2.34 Hz and 0.55\u2264\n              <jats:sup>19<\/jats:sup>\n              F\u22641.85) resulted in an odds ratio of 30.0 (CI 95%, 1.41\u2013638.15;\n              <jats:italic>P<\/jats:italic>\n              =0.029) for favorable post-MI remodeling.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              Multinuclear\n              <jats:sup>1<\/jats:sup>\n              H\/\n              <jats:sup>19<\/jats:sup>\n              F magnetic resonance imaging allows the simultaneous assessment of inflammation and elastin remodeling in a murine MI model. The interplay of these biological processes affects cardiac outcome and may have potential for improved diagnosis and personalized treatment.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.117.007453","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T18:34:52Z","timestamp":1546886092000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling After Myocardial Infarction"],"prefix":"10.1161","volume":"11","author":[{"given":"Isabel T.","family":"Ramos","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, United Kingdom (I.T.R., B.L., S.L., A.P., A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Henningsson","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Nezafat","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begon\u00f1a","family":"Lavin","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, United Kingdom (I.T.R., B.L., S.L., A.P., A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Lorrio","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, United Kingdom (I.T.R., B.L., S.L., A.P., A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gebhardt","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Germany (P.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Protti","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Eykyn","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo E.","family":"Andia","sequence":"additional","affiliation":[{"name":"Radiology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago (M.E.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Flo\u00f6gel","sequence":"additional","affiliation":[{"name":"Department of Molecular Cardiology, Heinrich Heine University Duesseldorf, Germany (U.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkystis","family":"Phinikaridou","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, United Kingdom (I.T.R., B.L., S.L., A.P., A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Cardiovascular Medicine and Sciences, King\u2019s College London British Heart Foundation Centre of Excellence, United Kingdom (I.T.R., B.L., S.L., A.P., A.M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene\u00e9 M.","family":"Botnar","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, United Kingdom (I.T.R., M.H., M.N., B.L., S.L., P.G., A.P., T.R.E., A.P., R.M.B.)."},{"name":"Escuela de Ingenier\u00eda, Pontificia Universidad Catolica de Chile, Santiago 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