{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:43:42Z","timestamp":1773031422745,"version":"3.50.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              Left ventricular (LV) twist mechanics are augmented with both acute and chronic hypoxemia. Although the underlying mechanisms remain unknown, sympathetic activation and a direct effect of hypoxemia on the myocardium have been proposed, the latter of which may produce subendocardial dysfunction that is masked by larger subepicardial torque. This study therefore sought to (1) determine the individual and combined influences of \u03b2\n              <jats:sub>1<\/jats:sub>\n              -AR (\u03b2\n              <jats:sub>1<\/jats:sub>\n              -adrenergic receptor) stimulation and peripheral O\n              <jats:sub>2<\/jats:sub>\n              saturation (Sp\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              ) on LV twist in acute and chronic hypoxia and (2) elucidate whether endocardial versus epicardial mechanics respond differently to hypoxia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Twelve males (27\u00b14 years) were tested near sea level in acute hypoxia (Sp\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              =82\u00b14%) and following 3 to 6 days at 5050 m (high altitude; Sp\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              =83\u00b13%). In both settings, participants received infusions of \u03b2\n              <jats:sub>1<\/jats:sub>\n              -AR blocker esmolol and volume-matched saline (double-blind, randomized). LV mechanics were assessed with 2-dimensional speckle-tracking echocardiography, and region-specific analysis to compare subendocardial and subepicardial mechanics.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              At sea level, compared with baseline (14.8\u00b13.0\u00b0) LV twist was reduced with esmolol (11.2\u00b13.3\u00b0;\n              <jats:italic>P<\/jats:italic>\n              =0.007) and augmented during hypoxia (19.6\u00b14.9\u00b0;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), whereas esmolol+hypoxia augmented twist compared with esmolol alone (16.5\u00b13.3\u00b0;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). At 5050 m, LV twist was increased compared with sea level (19.5\u00b15.4\u00b0;\n              <jats:italic>P<\/jats:italic>\n              =0.004), and reduced with esmolol (13.0\u00b13.8\u00b0;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and Sp\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              normalization (12.8\u00b13.4\u00b0;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Moreover, esmolol+normalized Sp\n              <jats:sc>o<\/jats:sc>\n              <jats:sub>2<\/jats:sub>\n              lowered twist further than esmolol alone (10.5\u00b13.1\u00b0;\n              <jats:italic>P<\/jats:italic>\n              =0.036). There was no mechanics-derived evidence of endocardial dysfunction with hypoxia at sea level or high altitude.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>\n              These findings suggest LV twist is augmented in hypoxia via \u03b2\n              <jats:sub>1<\/jats:sub>\n              -AR\u2013dependent and \u03b2\n              <jats:sub>1<\/jats:sub>\n              -AR\u2013independent mechanisms (eg, \u03b1\n              <jats:sub>1<\/jats:sub>\n              -AR stimulation), but does not appear to reflect endocardial dysfunction.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.118.008455","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T17:42:03Z","timestamp":1557250923000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Left Ventricular Twist Is Augmented in Hypoxia by \u03b2\n            <sub>1<\/sub>\n            -Adrenergic\u2013Dependent and \u03b2\n            <sub>1<\/sub>\n            -Adrenergic\u2013Independent Factors, Without Evidence of Endocardial Dysfunction"],"prefix":"10.1161","volume":"12","author":[{"given":"Alexandra M.","family":"Williams","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, The University of British Columbia, Kelowna, Canada (A.M.W., P.N.A.)."},{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada (A.M.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, The University of British Columbia, Kelowna, Canada (A.M.W., P.N.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Anholm","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada (A.M.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Gasho","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada (A.M.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prajan","family":"Subedi","sequence":"additional","affiliation":[{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada (A.M.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Stembridge","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Section, VA Loma Linda Healthcare System, Loma Linda, CA (J.D.A., C.G., P.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2008.03.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00995.2014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev166"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00233.2014"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.259.3.H784"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.110"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00361545"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.02.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91000-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00518.2003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.04.012"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-015-0614-1"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP275278"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.040568"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2015.1071876"},{"key":"e_1_3_3_17_2","first-page":"53","article-title":"Medex 2015: The key role of cardiac mechanics to maintain biventricular function at high altitude.","volume":"570","author":"Maufrais C","year":"2019","unstructured":"Maufrais, C, Rupp, T, Bouzat, P, Est\u00e8ve, F, Nottin, S, Walther, G, Verges, S. 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