{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:57:43Z","timestamp":1792879063489,"version":"4.5.0"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Arsenic exposure has been related to numerous adverse cardiovascular outcomes. The aim of this study was to investigate the cross-sectional and prospective association between arsenic exposure with echocardiographic measures of left ventricular (LV) geometry and functioning.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A total of 1337 young adult participants free of diabetes mellitus and cardiovascular disease were recruited from the SHFS (Strong Heart Family Study). The sum of inorganic and methylated arsenic concentrations in urine (\u03a3As) at baseline was used as a biomarker of arsenic exposure. LV geometry and functioning were assessed using transthoracic echocardiography at baseline and follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Mean follow-up was 5.6 years, and median (interquartile range) of \u03a3As was 4.2 (2.8\u20136.9) \u00b5g\/g creatinine. Increased arsenic exposure was associated with prevalent LV hypertrophy, with an odds ratio (95% CI) per a 2-fold increase in \u03a3As of 1.47 (1.05\u20132.08) in all participants and of 1.58 (1.04\u20132.41) among prehypertensive or hypertensive individuals. Measures of LV geometry, including LV mass index, left atrial systolic diameter, interventricular septum, and LV posterior wall thickness, were positively and significantly related to arsenic exposure. Among measures of LV functioning, stroke volume, and ejection fraction were associated with arsenic exposure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Arsenic exposure was related to an increase in LV wall thickness and LV hypertrophy in young American Indians with a low burden of cardiovascular risk factors. The relationship was stronger in participants with prehypertension or hypertension, suggesting that potential cardiotoxic effects of arsenic might be more pronounced in individuals already undergoing cardiovascular adaptive mechanisms following elevated systemic blood pressure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.119.009018","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T17:42:03Z","timestamp":1557250923000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":59,"title":["Association of Arsenic Exposure With Cardiac Geometry and Left Ventricular Function in Young Adults"],"prefix":"10.1161","volume":"12","author":[{"given":"Gernot","family":"Pichler","sequence":"first","affiliation":[{"name":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, NY (G.P., M.G.-P., A.N.-A.)."},{"name":"Area of Cardiometabolic and Renal 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J.R.)."},{"name":"Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.T.-P.)."},{"name":"Department of Chronic Diseases Epidemiology, National Center for Epidemiology, National Institutes for Health Carlos III, Madrid, Spain (M.T.-P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Umans","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute, and Georgetown University (J.U.)."},{"name":"Georgetown-Howard Universities Center for Clinical and Translational Science, Washington DC (J.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle","family":"Best","sequence":"additional","affiliation":[{"name":"Missouri Breaks Industries Research, Inc, Timber  Lake (L.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Genetics, Texas Biomedical Research 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