{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:32:04Z","timestamp":1773405124206,"version":"3.50.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>\n              The induction of matrix metalloproteinases (MMPs) and reduction in tissue inhibitors of MMPs (TIMPs) plays a role in ischemia\/reperfusion (I\/R) injury post-myocardial infarction (MI) and subsequent left ventricular remodeling. We developed a hybrid dual isotope single-photon emission computed tomography\/computed tomography approach for noninvasive evaluation of regional myocardial MMP activation with\n              <jats:sup>99m<\/jats:sup>\n              Tc-RP805 and dynamic\n              <jats:sup>201<\/jats:sup>\n              Tl for determination of myocardial blood flow, to quantify the effects of intracoronary delivery of recombinant TIMP-3 (rTIMP-3) on I\/R injury.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Studies were performed in control pigs (n=5) and pigs following 90-minute balloon occlusion\u2013induced ischemia\/reperfusion (I\/R) of left anterior descending artery (n=9). Before reperfusion, pigs with I\/R were randomly assigned to intracoronary infusion of rTIMP-3 (1.0 mg\/kg; n=5) or saline (n=4). Three days post-I\/R, dual isotope imaging was performed with\n              <jats:sup>99m<\/jats:sup>\n              Tc-RP805 and\n              <jats:sup>201<\/jats:sup>\n              Tl along with contrast cineCT to assess left ventricular function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The ischemic to nonischemic ratio of\n              <jats:sup>99m<\/jats:sup>\n              Tc-RP805 was significantly increased following I\/R in saline group (4.03\u00b11.40), and this ratio was significantly reduced with rTIMP-3 treatment (2.22\u00b10.57;\n              <jats:italic>P<\/jats:italic>\n              =0.03). This reduction in MMP activity in the MI-rTIMP-3 treatment group was associated with an improvement in relative MI region myocardial blood flow compared with the MI-saline group and improved myocardial strain in the MI region.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We have established a novel hybrid single-photon emission computed tomography\/computed tomography imaging approach for the quantitative assessment of regional MMP activation, myocardial blood flow, and cardiac function post-I\/R that can be used to evaluate therapeutic interventions such as intracoronary delivery of rTIMP-3 for reduction of I\/R injury in the early phases of post-MI remodeling.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.119.009055","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T10:03:02Z","timestamp":1573466582000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic\n            <sup>201<\/sup>\n            Tl Single-Photon Emission Computed Tomography\/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling"],"prefix":"10.1161","volume":"12","author":[{"given":"Stephanie L.","family":"Thorn","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine (S.L.T., A.F., M.R.S., A.J.S.), Yale University, School of Medicine, New Haven, CT."},{"name":"Yale Translational Research Imaging Center, Department of Internal Medicine, New Haven, CT (S.L.T., A.F., M.R.S., A.J.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayne C.","family":"Barlow","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Surgery, Cardiovascular Translational Research Center, WJB Dorn Veteran Affairs Medical Center, University of South Carolina School of Medicine, Columbia (S.C.B., H.D., J.J., K.Z., F.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Feher","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine (S.L.T., A.F., M.R.S., A.J.S.), Yale University, School of Medicine, New Haven, CT."},{"name":"Yale Translational Research Imaging Center, Department of Internal Medicine, New Haven, CT (S.L.T., A.F., M.R.S., A.J.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchel R.","family":"Stacy","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Internal Medicine (S.L.T., A.F., M.R.S., A.J.S.), Yale University, School of Medicine, New Haven, CT."},{"name":"Yale Translational Research Imaging Center, Department of Internal Medicine, New Haven, CT (S.L.T., A.F., M.R.S., A.J.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Doviak","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Surgery, Cardiovascular Translational Research Center, WJB Dorn Veteran Affairs Medical Center, University of South Carolina School of Medicine, Columbia (S.C.B., H.D., J.J., K.Z., F.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Surgery, Cardiovascular Translational Research Center, WJB Dorn Veteran Affairs Medical Center, University of South Carolina School of Medicine, Columbia (S.C.B., H.D., J.J., K.Z., F.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kia","family":"Zellars","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Surgery, Cardiovascular Translational Research Center, WJB Dorn Veteran Affairs Medical Center, University of South Carolina School of Medicine, Columbia (S.C.B., H.D., J.J., K.Z., F.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Renaud","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, ON, Canada (J.M.R., R.K., R.dK.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, ON, Canada (J.M.R., R.K., R.dK.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"deKemp","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, ON, Canada (J.M.R., R.K., R.dK.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarif Y.","family":"Khakoo","sequence":"additional","affiliation":[{"name":"Amgen, CardioMetabolic Disorders, South San Francisco, CA (A.Y.K., T.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TaeWeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Amgen, CardioMetabolic Disorders, South San Francisco, CA (A.Y.K., T.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis G.","family":"Spinale","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, Surgery, Cardiovascular Translational Research Center, WJB Dorn Veteran Affairs Medical Center, University of South Carolina School of Medicine, Columbia (S.C.B., H.D., J.J., K.Z., F.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert 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