{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:41:23Z","timestamp":1781858483847,"version":"3.54.5"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Mitral regurgitation is frequently complicated with atrial fibrillation without apparent organic changes in the leaflet, which occasionally improves after successful radiofrequency catheter ablation. We aimed to evaluate a possible geometric effect of radiofrequency catheter ablation on the mitral valve apparatus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Forty-three consecutive patients who underwent successful catheter ablation for persistent atrial fibrillation (maintaining sinus rhythm for 6 months after their procedure) were examined by serial real-time 3-dimensional transesophageal echocardiography before and 6 months after catheter ablation. Mitral valve complex geometry was measured using dedicated software for 3-dimensional transesophageal echocardiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Mitral valve apparatus showed significant reverse remodeling along with left atrial reverse remodeling 6 months after successful catheter ablation (50.5 [39.2\u201361.0] versus 36.4 [28.9\u201343.1] mL\/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The degree of mitral regurgitation decreased in a majority of patients (mitral regurgitation jet area; 1.83 [0.78\u20133.09] versus 0.77 [0.36\u20131.47] cm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Annular area significantly decreased (5.32\u00b10.91 versus 4.73\u00b10.76 cm\n              <jats:sup>2<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in both anterior-posterior and medial-lateral directions. Mitral annular contraction significantly recovered after maintaining sinus rhythm for 6 months (7.51 [4.82\u20139.62]% versus 9.71 [6.27\u201313.85]%;\n              <jats:italic>P<\/jats:italic>\n              =0.008). There were no significant changes in tenting volume or tenting height (0.46 [0.27\u20130.89] versus 0.51 [0.32\u20130.72] mL\/m\n              <jats:sup>2<\/jats:sup>\n              ,\n              <jats:italic>P<\/jats:italic>\n              =0.744; 2.34 [1.75\u20133.48] versus 2.76 [1.99\u20133.08] mm\/m\n              <jats:sup>2<\/jats:sup>\n              ,\n              <jats:italic>P<\/jats:italic>\n              =0.717). The leaflet surface area also significantly decreased after catheter ablation (5.74 [5.01\u20136.33] versus 5.19 [4.63\u20135.64] cm\n              <jats:sup>2<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Maintaining sinus rhythm after successful catheter ablation promotes reverse remodeling in the mitral valve apparatus and improves so-called atrial functional mitral regurgitation. The positive geometric effect of catheter ablation would be expected to be a possible contributor to better outcomes in patients with atrial fibrillation, in addition to the postprocedural freedom from rhythm disturbance.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.119.009317","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T09:00:19Z","timestamp":1570611619000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Reverse Remodeling of the Mitral Valve Complex After Radiofrequency Catheter Ablation for Atrial Fibrillation"],"prefix":"10.1161","volume":"12","author":[{"given":"Shun","family":"Nishino","sequence":"first","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Morihisa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehiro","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Pathology,  Faculty of Medicine, University of Miyazaki, Japan (Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshisato","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Miyazaki Medical Association Hospital Cardiovascular Center, Japan (S.N., N.W., K.A., K.M., N.K., Y.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.21.2634"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.069"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.02.018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707855"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz085"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut252"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-1334"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.032"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet191"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2009.00904.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0435"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2017.03.013"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12629"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur098"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.026"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.10.014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14249"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01838-7"},{"key":"e_1_3_2_22_2","first-page":"312","article-title":"The role of atrial contraction in mitral valve closure.","volume":"10","author":"Timek T","year":"2001","unstructured":"Timek, T, Dagum, P, Lai, DT, Green, GR, Glasson, JR, Daughters, GT, Ingels, NB, Jr, Miller, DC. The role of atrial contraction in mitral valve closure. J Heart Valve Dis. 2001;10:312\u2013319.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.11.009"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.092"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007028"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.116.005451"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0887"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000031"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.119.009317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:39:31Z","timestamp":1715567971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.119.009317"}},"subtitle":["A Serial 3-Dimensional Echocardiographic Study"],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1161\/CIRCIMAGING.119.009317"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.119.009317","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e009317"}}