{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:48:26Z","timestamp":1792460906822,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Technetium-99 m pyrophosphate protocols for transthyretin cardiac amyloidosis diagnosis have variably used 1- and 3-hour imaging time points. We investigated whether imaging at 1 hour with superior efficiency had comparable diagnostic accuracy as 3-hour imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This is a registry analysis of patients with suspected transthyretin cardiac amyloidosis referred for technetium-99 m pyrophosphate at a single tertiary center from June 2015 through January 2019. Patients underwent planar and single-photon emission computed tomography (SPECT) imaging at 1 and 3 hours. A positive Tc-99m pyrophosphate study was defined by the presence of diffuse myocardial tracer uptake on SPECT. For planar imaging, visual semiquantitative (grades 0-3, \u22652 considered positive) and quantitative heart to contralateral ratios (\u22651.5 considered positive) were used.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Two hundred thirty-three patients (69% men; median age, 77 [69\u201383] years) underwent the study protocol. There were 60 (25.8%) patients with diffuse myocardial uptake, 1 (0.4%) with regional uptake, and 172 (73.8%) with no myocardial uptake. Results of SPECT were identical at 1 and 3 hours. Planar imaging at 1 hour had 98% sensitivity and 96% specificity. Planar grade 0 uptake or heart to contralateral ratio \u22641.2 and planar grade 3 uptake or heart to contralateral ratio \u22652.0 were always associated with negative and positive SPECT, respectively. For planar grades 1 and 2 uptake and heart to contralateral ratio 1.3 to 1.9, SPECT was needed to make a diagnosis. No patient with light-chain cardiac amyloidosis had positive SPECT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>An efficient 1-hour technetium-99 m pyrophosphate protocol had comparable diagnostic performance to a 3-hour protocol.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.119.010249","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T10:00:21Z","timestamp":1581933621000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Efficient 1-Hour Technetium-99 m Pyrophosphate Imaging Protocol for the Diagnosis of Transthyretin Cardiac Amyloidosis"],"prefix":"10.1161","volume":"13","author":[{"given":"Ahmad","family":"Masri","sequence":"first","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Bukhari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Nieves","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne S.","family":"Eisele","sequence":"additional","affiliation":[{"name":"The Aging Institute, University of Pittsburgh, Pittsburgh, PA (Y.S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Follansbee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Brownell","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Schelbert","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Soman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, PA (A.M., S.B, S.A., R.N., W.F., A.B., T.C.W., E.S., P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx350"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0415-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.10.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005066"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-016-0478-3"},{"key":"e_1_3_3_9_2","unstructured":"ASNC Practice Points: 99mTechnetium-Pyrophosphate Imaging for Transthyretin Cardiac Amyloidosis. The American Society of Nuclear Cardiology website. Availble at: http:\/\/www.asnc.org\/Files\/Practice%20Resources\/Practice%20Points\/ASNC%20Practice%20Point-99mTechnetiumPyrophosphateImaging2016.pdf. Accessed January 7 2020."},{"key":"e_1_3_3_10_2","unstructured":"ASNC Practice Points: 99mTechnetium-Pyrophosphate Imaging for Transthyretin Cardiac Amyloidosis. The American Society of Nuclear Cardiology website. Availble at: https:\/\/www.asnc.org\/content.asp?contentid=182. 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