{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:54:50Z","timestamp":1787792090086,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Late gadolinium enhancement (LGE) is an important prognostic marker in hypertrophic cardiomyopathy and an extent &gt;15% it is associated with high risk of sudden cardiac death. We proposed a novel method, the LGE-dispersion mapping, to assess heterogeneity of scar, and evaluated its prognostic role in patients with hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>One hundred eighty-three patients with hypertrophic cardiomyopathy and a low- or intermediate 5-year risk of sudden cardiac death underwent cardiac magnetic resonance imaging. A parametric map was generated from each LGE image. A score from 0 to 8 was assigned at every pixel of these maps, indicating the number of the surrounding pixels having different quality (nonenhancement, mild-enhancement, or hyperenhancement) from the central pixel. The Global Dispersion Score (GDS) was calculated as the average score of all the pixels of the images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      During a median follow-up time of 6 (25th\u201375th, 4\u201310) years, 22 patients had hard cardiac events (sudden cardiac death, appropriate implantable cardioverter-defibrillator therapy, resuscitated cardiac arrest, and sustained ventricular tachycardia). Kaplan-Meier analysis showed that patients with GDS&gt;0.86 had worse prognosis than those with lower GDS (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). GDS&gt;0.86 was the only independent predictor of cardiac events (hazard ratio, 9.9 [95% CI, 2.9\u201334.6],\n                      <jats:italic>P<\/jats:italic>\n                      =0.0003). When compared with LGE extent &gt;15%, GDS improved the classification of risk in these patients (net reclassification improvement, 0.39 [95% CI, 0.11\u20130.72],\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>LGE-dispersion mapping is a marker of scar heterogeneity and provides a better risk stratification than LGE presence and its extent in patients with hypertrophic cardiomyopathy and a low-intermediate 5-year risk of sudden cardiac death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.120.010489","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T05:00:38Z","timestamp":1592283638000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Late Gadolinium Enhancement\u2013Dispersion Mapping"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-915X","authenticated-orcid":false,"given":"Giovanni Donato","family":"Aquaro","sequence":"first","affiliation":[{"name":"Fondazione Toscana G. Monasterio, Pisa, Italy (G.D.A., C.G., G.T., N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysanthos","family":"Grigoratos","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. Monasterio, Pisa, Italy (G.D.A., C.G., G.T., N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bracco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Messina, Messina, Italy (A.B., S.C., G.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Proclemer","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy (A.P., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Todiere","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. Monasterio, Pisa, Italy (G.D.A., C.G., G.T., N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Martini","sequence":"additional","affiliation":[{"name":"Fondazione Toscana G. Monasterio, Pisa, Italy (G.D.A., C.G., G.T., N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacob Ghebru","family":"Habtemicael","sequence":"additional","affiliation":[{"name":"University of Chieti, Chieti, Italy (Y.G.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scipione","family":"Carerj","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Messina, Messina, Italy (A.B., S.C., G.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardio-thoraco-vascular Department, University of Trieste, Trieste, Italy (A.P., G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Di Bella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Messina, Messina, Italy (A.B., S.C., G.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2016:13:3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.026"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.035"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.060"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.768119"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.07.020"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(03)00189-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.04.060"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.963819"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.045"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25450"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.076"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.05.047"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.07.023"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190101"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12783"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4092469"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.120.010489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:15:13Z","timestamp":1715552113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.120.010489"}},"subtitle":["A New Magnetic Resonance Imaging Technique to Assess Prognosis in Patients With Hypertrophic Cardiomyopathy and Low-Intermediate 5-Year Risk of Sudden Death"],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1161\/CIRCIMAGING.120.010489"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.120.010489","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2020-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e010489"}}