{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:36:31Z","timestamp":1780508191349,"version":"3.54.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Pharmacological stress testing can help to uncover pathological hemodynamic conditions and is, therefore, used in the clinical routine to assess patients with structural heart diseases such as aortic coarctation with borderline indication for treatment. The aim of this study was to develop and test a reduced-order model predicting dobutamine stress induced pressure gradients across the coarctation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The reduced-order model was developed based on n=21 imaging data sets of patients with aortic coarctation and a meta-analysis of subjects undergoing dobutamine stress testing. Within an independent test cohort of n=21 patients with aortic coarctation, the results of the model were compared with dobutamine stress testing during catheterization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In n=19 patients responding to dobutamine stress testing, pressure gradients across the coarctation during dobutamine stress increased from 15.7\u00b15.1 to 33.6\u00b110.3 mm Hg (paired\n              <jats:italic>t<\/jats:italic>\n              test,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The model-predicted pressure gradients agreed with catheter measurements with a mean difference of \u22122.2 mm Hg and a limit of agreement of \u00b111.16 mm Hg according to Bland-Altman analysis. Significant equivalence between catheter-measured and simulated pressure gradients during stress was found within the study cohort (two 1-sided tests of equivalence with a noninferiority margin of 5.0 mm Hg, 33.6\u00b110.33 versus 31.5\u00b111.15 mm Hg,\n              <jats:italic>P<\/jats:italic>\n              =0.021).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The developed reduced-order model can instantly predict dobutamine-induced hemodynamic changes with accuracy equivalent to heart catheterization in patients with aortic coarctation. The method is easy to use, available as a web-based calculator, and provides a promising alternative to conventional stress testing in the clinical routine.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02591940.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.120.011523","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T20:22:55Z","timestamp":1613506975000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Image-Based Computational Model Predicts Dobutamine-Induced Hemodynamic Changes in Patients With Aortic Coarctation"],"prefix":"10.1161","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct02591940","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-5905","authenticated-orcid":true,"given":"Kilian","family":"Runte","sequence":"first","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Brosien","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-8055","authenticated-orcid":true,"given":"Charlotte","family":"Schubert","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Nordmeyer","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-5271","authenticated-orcid":true,"given":"Peter","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."},{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, Heart and Diabetes Center NRW, Ruhr-University Bochum, Bad Oeynhausen, Germany (S.S.)."},{"name":"German Center for Cardiovascular Research, Partner Site Berlin, Germany (S.S., F.B., T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-1557","authenticated-orcid":true,"given":"Felix","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."},{"name":"German Center for Cardiovascular Research, Partner Site Berlin, Germany (S.S., F.B., T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hennemuth","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Fraunhofer Institute for Medical Image Computing-MEVIS, Bremen, Germany (A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Kuehne","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."},{"name":"German Center for Cardiovascular Research, Partner Site Berlin, Germany (S.S., F.B., T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Kelm","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Department of Congenital Heart Disease\/Pediatric Cardiology, German Heart Center Berlin, Germany (K.R., C.S., J.N., P.K., S.S., F.B., T.K., M.K.)."},{"name":"Berlin Institute of Health, Germany (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-3179","authenticated-orcid":true,"given":"Leonid","family":"Goubergrits","sequence":"additional","affiliation":[{"name":"Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Germany (K.R., K.B., C.S., A.H., T.K., M.K., L.G.)."},{"name":"Einstein Center Digital Future, Berlin, Germany (L.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.914788"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652016"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht350"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951109991818"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821b1f10"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000603"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001197"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(99)00066-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.01717-5.x"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0001-2998(99)80018-x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.058"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.08.002"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.88.1.15"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.04.032"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.4004996"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00043"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90599-x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.37.2.149"},{"key":"e_1_3_4_21_2","unstructured":"Tost DA. Two one-sided tests of equivalence. Stata Software Package. 2019;version 3.1.0. Accessed January 2021. https:\/\/www.alexisdinno.com\/stata\/tost.html"},{"key":"e_1_3_4_22_2","unstructured":"International Electrotechnical Commission. Medical electrical equipment - Part 2-34: Particular requirements for the basic safety and essential performance of invasive blood pressure monitoring equipment. 2011;IEC60601:2\u201334 (3rd Ed). Accessed January 25 2021. https:\/\/webstore.iec.ch\/publication\/2650."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319872567"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(01)02293-7"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2000.tb01295.x"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951118000239"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.03.017"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26230"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2018.12.016"},{"key":"e_1_3_4_30_2","first-page":"20","article-title":"Utility of the dobutamine stress echocardiography in the evaluation of the effects of a surgical repair of aortic coarctation in children.","volume":"16","author":"Banaszak P","year":"2009","unstructured":"Banaszak, P, Szkutnik, M, Kusa, J, Banaszak, B, Bia\u0142kowski, J. Utility of the dobutamine stress echocardiography in the evaluation of the effects of a surgical repair of aortic coarctation in children. Cardiol J. 2009;16:20\u201325.","journal-title":"Cardiol J"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90079-x"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951116001670"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1047951101000749"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.03.029"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.120.011523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:16:07Z","timestamp":1715566567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.120.011523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1161\/CIRCIMAGING.120.011523"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.120.011523","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e011523"}}