{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:59:19Z","timestamp":1791345559073,"version":"4.3.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Echocardiographic deformation-based ratios and novel multi-parametric scores have been suggested to discriminate transthyretin cardiac amyloidosis (ATTR-CM) from other causes of increased left ventricular wall thickness among patients referred for ATTR-CM evaluation. Their relative predictive accuracy has not been well studied. We sought to (1) identify echocardiographic parameters predictive of ATTR-CM and (2) compare the diagnostic accuracy of these parameters in patients with suspected ATTR-CM referred for technetium-99m-pyrophosphate scintigraphy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Echocardiograms from 598 patients referred to 3 major amyloidosis centers for technetium-99m-pyrophosphate to detect ATTR-CM were analyzed, including longitudinal strain (LS) analysis. Deformation ratios (septal apex to base ratio, relative apical sparing, ejection fraction to global LS), a multi-center European increased wall thickness score, and Mayo Clinic derived ATTR score (transthyretin cardiac amyloidosis score) were calculated. A logistic regression model was used to identify the parameters that best associated with a diagnosis of ATTR-CM. Comparison of the diagnostic capacity of the parameters was performed by receiver operating characteristic curves and the area under the curve (AUC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Over half of the subjects (54.2%) were diagnosed with ATTR-CM (78% were men, median age of 76 years). Age, inferolateral wall thickness, and basal LS were the strongest predictors of ATTR-CM, AUC of 0.87 (95% CI: 0.83, 0.90), superior to the increased wall thickness score AUC of 0.78 (95% CI: 0.73, 0.83;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.004). An inferolateral wall thickness of \u226514 mm (AUC: 0.73) was as accurate as the published cut-offs for transthyretin cardiac amyloidosis score and septal apex to base (AUC: 0.72 and 0.69,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.8 and\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.1, respectively), and was superior to ejection fraction to global LS and relative apical sparing (AUC: 0.64 and 0.53,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001, respectively). A cut-off of \u2265\u22128% for average basal LS (AUC: 0.76, CI: 0.72\u20130.79) had a similar area under the curve to transthyretin cardiac amyloidosis score (TCAS) (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.2); outperforming the other indices (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Inferolateral wall thickness and average basal LS performed as well as or better than more complex echo ratios and multiparametric scores to predict ATTR-CM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.122.014645","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T19:00:40Z","timestamp":1668538840000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Optimal Echocardiographic Parameters to Improve the Diagnostic Yield of Tc-99m-Bone Avid Tracer Cardiac Scintigraphy for Transthyretin Cardiac Amyloidosis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-2151","authenticated-orcid":true,"given":"Sarah AM","family":"Cuddy","sequence":"first","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."},{"name":"CV imaging program, Cardiovascular Division and Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., G.O., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-3048","authenticated-orcid":true,"given":"Yesh","family":"Datar","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."},{"name":"CV imaging program, Cardiovascular Division and Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., G.O., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Ovsak","sequence":"additional","affiliation":[{"name":"CV imaging program, Cardiovascular Division and Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., G.O., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3507-681X","authenticated-orcid":true,"given":"Sunil","family":"Saith","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.S., M.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-5974","authenticated-orcid":true,"given":"Sean P.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camden P.","family":"Bay","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (C.P.B., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Haddad","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-9309","authenticated-orcid":true,"given":"Brian","family":"Lilleness","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Muralidhar","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Pipilas","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Vuong","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-8960","authenticated-orcid":true,"given":"Eric","family":"Guardino","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-0526","authenticated-orcid":true,"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.S., M.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-4413","authenticated-orcid":true,"given":"Frederick L.","family":"Ruberg","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine\/Boston Medical Center, Boston, MA (B.L., V.M., A.P., J.V., E.G., F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Falk","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-1185","authenticated-orcid":true,"given":"Sharmila","family":"Dorbala","sequence":"additional","affiliation":[{"name":"Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., S.P.M., M.H., R.H.F., S.D.)."},{"name":"CV imaging program, Cardiovascular Division and Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (S.A.M.C., Y.D., G.O., S.D.)."},{"name":"Division of Nuclear Medicine, Department of Radiology, Brigham and Women\u2019s Hospital, Boston, MA (C.P.B., S.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.02.016"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302353"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000683"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005588"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.10.011"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.1781"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.06.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.10.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.11.008"},{"key":"e_1_3_3_13_2","volume-title":"caret: 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