{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:10:33Z","timestamp":1790356233245,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Cardiac allograft vasculopathy (CAV) is an obliterative and diffuse form of vasculopathy and is the most common cause of long-term cardiovascular mortality in heart transplant patients. This study aimed to investigate the diagnostic performance of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc and\n                      <jats:sup>201<\/jats:sup>\n                      Tl tracers in the assessment of CAV using cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) for myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantification, which was further validated using\n                      <jats:sup>13<\/jats:sup>\n                      N-NH\n                      <jats:sub>3<\/jats:sub>\n                      positron emission tomography (PET).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty-eight patients with prior heart transplantation who underwent CZT SPECT and\n                      <jats:sup>13<\/jats:sup>\n                      N-NH\n                      <jats:sub>3<\/jats:sub>\n                      PET dynamic scans were included in this study. CZT SPECT with\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-sestamibi was used in the first 19 patients and\n                      <jats:sup>201<\/jats:sup>\n                      Tl-chloride for the remaining patients. To determine the diagnostic accuracy of angiographically defined moderate-to-severe CAV, the analysis included patients who underwent angiographic examinations within 1 year of their second scan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were no significant differences in the patient characteristics between the\n                      <jats:sup>201<\/jats:sup>\n                      Tl and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc tracer groups. Both\n                      <jats:sup>201<\/jats:sup>\n                      Tl and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc CZT SPECT-derived stress MBF and MFR values globally and in 3 coronary territories showed good correlations with\n                      <jats:sup>13<\/jats:sup>\n                      N-NH\n                      <jats:sub>3<\/jats:sub>\n                      PET. The\n                      <jats:sup>201<\/jats:sup>\n                      Tl and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc cohorts did not differ significantly in the correlation coefficients of CZT SPECT versus PET for MBF and MFR, except for stress MBF (\n                      <jats:sup>201<\/jats:sup>\n                      Tl:0.95 versus\n                      <jats:sup>99m<\/jats:sup>\n                      Tc:0.80,\n                      <jats:italic>P<\/jats:italic>\n                      =0.03).\n                      <jats:sup>201<\/jats:sup>\n                      Tl and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc CZT SPECT were satisfactory for detecting PET MFR &lt;2.0 (\n                      <jats:sup>201<\/jats:sup>\n                      Tl area under the curve, 0.92 [0.71\u20130.99],\n                      <jats:sup>99m<\/jats:sup>\n                      Tc area under the curve, 0.87 [0.64\u20130.97]) and angiographically defined moderate-to-severe CAV, and CZT SPECT results were comparable to that of\n                      <jats:sup>13<\/jats:sup>\n                      N-NH\n                      <jats:sub>3<\/jats:sub>\n                      PET (CZT area under the curve, 0.90 [0.70\u20130.99], PET area under the curve, 0.86 [0.64\u20130.97]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      This small study suggests that CZT SPECT using\n                      <jats:sup>201<\/jats:sup>\n                      Tl and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc tracers showed comparable MBF and MFR, and the results correlated well with those of\n                      <jats:sup>13<\/jats:sup>\n                      N-NH\n                      <jats:sub>3<\/jats:sub>\n                      PET. Hence, CZT SPECT with\n                      <jats:sup>201<\/jats:sup>\n                      Tl or\n                      <jats:sup>99m<\/jats:sup>\n                      Tc tracers can be used to detect moderate-to-severe CAV in patients with prior heart transplantation. However, validation using larger studies is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.122.015034","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:00:30Z","timestamp":1686718830000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Myocardial Flow Assessment After Heart Transplantation Using Dynamic Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography With\n                    <sup>201<\/sup>\n                    Tl and\n                    <sup>99m<\/sup>\n                    Tc Tracers and Validated by\n                    <sup>13<\/sup>\n                    N-NH\n                    <sub>3<\/sub>\n                    Positron Emission Tomography"],"prefix":"10.1161","volume":"16","author":[{"given":"Kuan-Yin","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, 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