{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T22:27:12Z","timestamp":1787264832971,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The contemporary burden and characteristics of coronary atherosclerosis, assessed using coronary computed tomography angiography (CCTA), is unknown among asymptomatic adults with diabetes and prediabetes in the United States. The pooled cohort equations and coronary artery calcium (CAC) score stratify atherosclerotic cardiovascular disease risk, but their association with CCTA findings across glycemic categories is not well established.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Asymptomatic adults without atherosclerotic cardiovascular disease enrolled in the Miami Heart Study were included. Participants underwent CAC and CCTA testing and were classified into glycemic categories. Prevalence of coronary atherosclerosis (any plaque, noncalcified plaque, plaque with \u22651 high-risk feature, maximal stenosis \u226550%) assessed by CCTA was described across glycemic categories and further stratified by pooled cohort equations\u2013estimated atherosclerotic cardiovascular disease risk and CAC score. Adjusted logistic regression was used to evaluate the associations between glycemic categories and coronary outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Among 2352 participants (49.5% women), the prevalence of euglycemia, prediabetes, and diabetes was 63%, 30%, and 7%, respectively. Coronary plaque was more commonly present across worsening glycemic categories (euglycemia, 43%; prediabetes, 58%; diabetes, 69%), and similar pattern was observed for other coronary outcomes. In adjusted analyses, compared with euglycemia, prediabetes and diabetes were each associated with higher odds of any coronary plaque (OR, 1.30 [95% CI, 1.05\u20131.60] and 1.75 [1.17\u20132.61], respectively), noncalcified plaque (OR, 1.47 [1.19\u20131.81] and 1.99 [1.38\u20132.87], respectively), and plaque with \u22651 high-risk feature (OR, 1.65 [1.14\u20132.39] and 2.53 [1.48\u20134.33], respectively). Diabetes was associated with stenosis \u226550% (OR, 3.01 [1.79\u20135.08]; reference=euglycemia). Among participants with diabetes and estimated atherosclerotic cardiovascular disease risk &lt;5%, 46% had coronary plaque and 10% had stenosis \u226550%. Among participants with diabetes and CAC=0, 30% had coronary plaque and 3% had stenosis \u226550%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Among asymptomatic adults, worse glycemic status is associated with higher prevalence and extent of coronary atherosclerosis, high-risk plaque, and stenosis. In diabetes, CAC was more closely associated with CCTA findings and informative in a larger population than the pooled cohort equations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.123.015314","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:01:08Z","timestamp":1695978068000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Coronary Atherosclerosis Across the Glycemic Spectrum Among Asymptomatic Adults: The Miami Heart Study at Baptist Health South Florida"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2002-4096","authenticated-orcid":true,"given":"Kershaw V.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart &amp; Vascular Center, TX (K.V.P., J.V.-E., S.L., M.B.T., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1946","authenticated-orcid":true,"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Harbor-UCLA Medical Center, Torrance, CA (M.J.B.)."},{"name":"David Geffen School of Medicine, University of California, Los Angeles (M.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-5093","authenticated-orcid":true,"given":"Javier","family":"Valero-Elizondo","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart &amp; Vascular Center, TX (K.V.P., J.V.-E., S.L., M.B.T., K.N.)."},{"name":"Center for Outcomes Research, Houston Methodist (J.V.-E., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-3629","authenticated-orcid":true,"given":"Shubham","family":"Lahan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart &amp; Vascular Center, TX (K.V.P., J.V.-E., S.L., M.B.T., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozab S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."},{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami (S.S.A., T.F., R.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad B.","family":"Taha","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart &amp; Vascular Center, TX (K.V.P., J.V.-E., S.L., M.B.T., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-9683","authenticated-orcid":true,"given":"Michael J.","family":"Blaha","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore (M.J.B., M.C.-A., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-6562","authenticated-orcid":true,"given":"Ron","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital Heart and Vascular Center, and Harvard Medical School, Boston, MA (R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-3287","authenticated-orcid":true,"given":"Michael D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (M.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9651-3836","authenticated-orcid":true,"given":"Ambarish","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (A.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Arias","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Feldman","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."},{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami (S.S.A., T.F., R.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-2886","authenticated-orcid":true,"given":"Ricardo C.","family":"Cury","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."},{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami (S.S.A., T.F., R.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-2337","authenticated-orcid":true,"given":"Miguel","family":"Cainzos-Achirica","sequence":"additional","affiliation":[{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore (M.J.B., M.C.-A., K.N.)."},{"name":"Department of Cardiology, Hospital del Mar and Hospital del Mar Research Institute, Barcelona, Spain (M.C.-A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-2830","authenticated-orcid":true,"given":"Svati H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Ziffer","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fialkow","sequence":"additional","affiliation":[{"name":"Miami Cardiac and Vascular Institute, Baptist Health South Florida (S.S.A., L.A., T.F., R.C.C., J.A.Z., J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-2269","authenticated-orcid":true,"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Prevention and Wellness, Department of Cardiology, Houston Methodist DeBakey Heart &amp; Vascular Center, TX (K.V.P., J.V.-E., S.L., M.B.T., K.N.)."},{"name":"Center for Outcomes Research, Houston Methodist (J.V.-E., K.N.)."},{"name":"Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore (M.J.B., M.C.-A., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"Centers for Disease Control and Prevention. National Diabetes Statistics Report Website. Accessed August 29 2022. https:\/\/www.cdc.gov\/diabetes\/data\/statistics-report\/index.html"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.05.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.12.024"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1074"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.069"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006973"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000678"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003528"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.03.335"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.03.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2021.100202"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0281"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.306256"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.017"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcad007"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000343"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1115"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319846715"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.10.017"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2020.12.005"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025483"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15825"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e3282f3fbef"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.11.028"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev106"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-015-0213-5"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1844"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.123.015314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:29:52Z","timestamp":1715567392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.123.015314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1161\/CIRCIMAGING.123.015314"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.123.015314","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}