{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:04:56Z","timestamp":1789034696807,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Left ventricular (LV) hypertrophy occurs in both aortic stenosis (AS) and systemic hypertension (HTN) in response to wall stress. However, differentiation of hypertrophy due to these 2 etiologies is lacking. The aim was to study the 3-dimensional geometric remodeling pattern in severe AS pre- and postsurgical aortic valve replacement and to compare with HTN and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Ninety-one subjects (36 severe AS, 19 HTN, and 36 healthy controls) underwent cine cardiac magnetic resonance. Cardiac magnetic resonance was repeated 8 months post-aortic valve replacement (n=18). Principal component analysis was performed on the 3-dimensional meshes reconstructed from 109 cardiac magnetic resonance scans of 91 subjects at end-diastole. Principal component analysis modes were compared across experimental groups together with conventional metrics of shape, strain, and scar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A unique AS signature was identified by wall thickness linked to a LV left-right axis shift and a decrease in short-axis eccentricity. HTN was uniquely linked to increased septal thickness. Combining these 3 features had good discriminative ability between AS and HTN (area under the curve, 0.792). The LV left-right axis shift was not reversible post-aortic valve replacement, did not associate with strain, age, or sex, and was predictive of postoperative LV mass regression (R\n                      <jats:sup>2<\/jats:sup>\n                      =0.339,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Unique remodeling signatures might differentiate the etiology of LV hypertrophy. Preliminary findings suggest that LV axis shift is characteristic in AS, is not reversible post-aortic valve replacement, predicts mass regression, and may be interpreted to be an adaptive mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.123.016489","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T14:04:25Z","timestamp":1724162665000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension"],"prefix":"10.1161","volume":"17","author":[{"given":"Masliza","family":"Mahmod","sequence":"first","affiliation":[{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5571-7549","authenticated-orcid":true,"given":"Kenneth","family":"Chan","sequence":"additional","affiliation":[{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-1837","authenticated-orcid":true,"given":"Joao F.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering (J.F.F., H.-F.R.L., P.L.), King\u2019s College of London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Ariga","sequence":"additional","affiliation":[{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1239-9608","authenticated-orcid":true,"given":"Betty","family":"Raman","sequence":"additional","affiliation":[{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-7417","authenticated-orcid":true,"given":"Ernesto","family":"Zacur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering (E.Z.), University of Oxford, United 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Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-4763","authenticated-orcid":true,"given":"Kevin","family":"O\u2019Gallagher","sequence":"additional","affiliation":[{"name":"Department Cardiovascular Medicine (K.O.G.), King\u2019s College of London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5927-0230","authenticated-orcid":true,"given":"Saul G.","family":"Myerson","sequence":"additional","affiliation":[{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine (M.M., K.C., R.A., B.R., M.R., J.M.F., S.D., S.G.M., S.N.), University of Oxford, United 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