{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:24:35Z","timestamp":1757701475491,"version":"3.33.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>It is well understood that cancer therapies including chemotherapy, tyrosine kinase inhibitors, immune checkpoint inhibitors, and radiation can increase the risk of cardiovascular disease in patients with cancer. This can manifest as a multitude of pathologies including left ventricular dysfunction, myocarditis, cardiomyopathy, accelerated atherosclerosis, and coronary vasospasm. Multimodal cardiac imaging plays a critical role in diagnosing such pathologies by relying on noninvasive tools including echocardiograms, cardiac magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and coronary computed tomography angiography. These methods have unique considerations and in recent years have made significant progress in their diagnostic capabilities in this patient population. As the field of cardio-oncology continues to expand rapidly, guidance on the management of such toxicities and the development of imaging technologies is crucial. In this review, we present 2 complex cases of atherosclerosis and myocarditis in patients with cancer, highlighting our rationale for management and discussing the nuances of various cardiac imaging modalities.<\/jats:p>","DOI":"10.1161\/circimaging.124.015981","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:00:35Z","timestamp":1736330435000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology"],"prefix":"10.1161","volume":"18","author":[{"given":"Mohamad","family":"Khattab","sequence":"first","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (M.K., M.B., T.E.Z., L.A.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Baig","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (M.K., M.B., T.E.Z., L.A.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-2396","authenticated-orcid":true,"given":"Talal","family":"El Zarif","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (M.K., M.B., T.E.Z., L.A.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-8904","authenticated-orcid":true,"given":"Ana","family":"Barac","sequence":"additional","affiliation":[{"name":"Inova Heart Institute, Fairfax, VA (A.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-2223","authenticated-orcid":true,"given":"Maros","family":"Ferencik","sequence":"additional","affiliation":[{"name":"Knight Cardiovascular Institute, Oregon Health Sciences University, Portland (M.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana L.","family":"Henry","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth, Hanover, NH (M.L.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lopez-Mattei","sequence":"additional","affiliation":[{"name":"Lee Health Heart Institute, Fort Myers, FL (J.L.-M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-9902","authenticated-orcid":true,"given":"Alban","family":"Redheuil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, INSERM, CIC-1901, UNICO-GRECO Cardio-oncology Program, France (A.R., J.-E.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-3307","authenticated-orcid":true,"given":"Joe-Elie","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9, INSERM, CIC-1901, UNICO-GRECO Cardio-oncology Program, France (A.R., J.-E.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-9266","authenticated-orcid":true,"given":"Marielle","family":"Scherrer-Crosbie","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia (M.S.-C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-7454","authenticated-orcid":true,"given":"Eric H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California at Los Angeles (E.H.Y.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-3449","authenticated-orcid":true,"given":"Lauren A.","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (M.K., M.B., T.E.Z., L.A.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.743"},{"key":"e_1_3_3_3_2","volume-title":"Cardio-Oncology Practice Manual: A Companion to Braunwald\u2019s Heart Disease","author":"Herrmann J","year":"2022","unstructured":"Herrmann J. Cardio-Oncology Practice Manual: A Companion to Braunwald\u2019s Heart Disease. Elsevier Health Sciences; 2022."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2022.09.002"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2023.01.015"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey176"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa228"},{"key":"e_1_3_3_10_2","first-page":"205","article-title":"Myocardial perfusion imaging and cardiovascular outcomes in a cancer population.","volume":"36","author":"Chandra S","year":"2009","unstructured":"Chandra S, Lenihan DJ, Wei W, Yusuf SW, Tong AT. Myocardial perfusion imaging and cardiovascular outcomes in a cancer population. Tex Heart Inst J. 2009;36:205\u2013213.","journal-title":"Tex Heart Inst J"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-021-02825-1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-018-1458-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.022"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.07.029"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716734"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286364"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40959-021-00118-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(68)90143-4"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2021.100049"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-1180"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa051"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021210814"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2022.11.004"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001174"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.01.050"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211765"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246764"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.049"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.121.012459"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28890"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.072"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.124.015981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T19:01:02Z","timestamp":1737486062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.124.015981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1161\/CIRCIMAGING.124.015981"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.124.015981","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"type":"print","value":"1941-9651"},{"type":"electronic","value":"1942-0080"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}