{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:45:35Z","timestamp":1790703935643,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              Coronary flow capacity (CFC) is a measure that integrates hyperemic myocardial blood flow and myocardial flow reserve to quantify the pathophysiological impact of coronary artery disease on vasodilator capacity. We assessed the prognostic value of CFC derived from\n              <jats:sup>82<\/jats:sup>\n              Rb positron emission tomography\/computed tomography in patients with suspected coronary artery disease and normal myocardial perfusion imaging.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              We studied 1967 patients with suspected coronary artery disease and normal myocardial perfusion at the semiquantitative analysis of stress\/rest cardiac\n              <jats:sup>82<\/jats:sup>\n              Rb positron emission tomography\/computed tomography imaging. Coronary artery calcium scores were calculated and categorized into 3 groups: 0, 0.1 to 99.9, and \u2265100. Patients were classified as having myocardial steal, severely reduced CFC, moderately reduced CFC, mildly reduced CFC, minimally reduced CFC, or normal flow using previously defined thresholds. The outcome end points were myocardial infarction and cardiac death, whichever occurred first.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              During a mean time of 41\u00b127 months, 49 events occurred (2.5% cumulative event rate, with an annualized event rate of 0.5% person-years). At multivariable Cox analysis, coronary artery calcium score categories and impaired CFC resulted as independent predictors of events (both\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). The annualized event rate was higher in patients with impaired CFC compared with those with normal CFC (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.05). Kaplan-Meier analysis showed that patients with impaired CFC were at the highest risk of events.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients with suspected coronary artery disease and normal myocardial perfusion, impaired CFC is associated with a higher risk of cardiac events. Evaluating CFC can help identify patients\u2019 candidates for additional therapies to prevent future events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.124.016815","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T10:01:04Z","timestamp":1730973664000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic Value of Coronary Flow Capacity by\n            <sup>82<\/sup>\n            Rb PET in Patients With Suspected Coronary Artery Disease and Normal Myocardial Perfusion at Semiquantitative Imaging Analysis"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-731X","authenticated-orcid":true,"given":"Emilia","family":"Zampella","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Assante","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-1656","authenticated-orcid":true,"given":"Adriana","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-5315","authenticated-orcid":true,"given":"Teresa","family":"Mannarino","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-2997","authenticated-orcid":true,"given":"Valeria","family":"Gaudieri","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-4677","authenticated-orcid":true,"given":"Carmela","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University Federico II, Naples, Italy (E.Z., R.A., A.D., T.M., V.G., C.N., P.B., A.C., W.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthiban","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Central Manchester Foundation Trust, Manchester, United Kingdom (P.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Panico","sequence":"additional","affiliation":[{"name":"Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy (M. 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