{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:04:05Z","timestamp":1781816645441,"version":"3.54.5"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Accurate assessment of left ventricular filling pressure in patients with atrial fibrillation or flutter (AF) remains difficult. A novel 2-dimensional scoring system, visually assessing time difference between mitral valve and tricuspid valve opening (VMT) score, based on temporal analysis of early diastolic valve opening, could be applied to these patients. We aimed to determine the usefulness of the VMT score in patients with AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We analyzed 119 consecutive patients with AF who underwent cardiac catheterization as a derivation cohort. The diagnostic performance of the VMT score was further evaluated in an external data set containing 189 patients with AF. Elevated left ventricular filling pressure was defined as a mean pulmonary arterial wedge pressure \u226515 mm\u2005Hg. The time sequence of atrioventricular valve opening was visually assessed and scored (0, tricuspid valve first; 1, simultaneous; 2, mitral valve first). When the inferior vena cava was dilated, 1 point was added, and the VMT score was finally graded as 0 to 3. Conventional Doppler parameters to estimate left ventricular filling pressure were also measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Pulmonary arterial wedge pressure was elevated with an increase in the VMT score (0: 10\u00b13, 1: 13\u00b15, 2: 22\u00b17, 3: 27\u00b16 mm\u2005Hg;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001), resulting in a significant rise in pulmonary arterial wedge pressure from VMT score 1 to 2. VMT\u22652 predicted elevated pulmonary arterial wedge pressure with an accuracy of 87%, and the diagnostic accuracy of the VMT score was significantly higher than that of conventional Doppler parameters (\n              <jats:italic toggle=\"yes\">C<\/jats:italic>\n              index, 0.88 versus 0.54\u20130.68;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). In addition, VMT \u22652 showed an incremental predictive value over plasma brain natriuretic peptide levels (\n              <jats:italic toggle=\"yes\">C<\/jats:italic>\n              index, 0.79\u20130.93;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). In the external validation cohort, VMT\u22652 demonstrated acceptable accuracy of 72%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>VMT scoring was a useful echocardiographic marker of elevated left ventricular filling pressure and had an incremental benefit over practical biomarkers in patients with AF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.124.017134","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:14:43Z","timestamp":1731496483000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Validation of Left Ventricular Filling Pressure Evaluation by Order of Tricuspid and Mitral Valve Opening in Patients With Atrial Fibrillation"],"prefix":"10.1161","volume":"17","author":[{"given":"Hisao","family":"Nishino","sequence":"first","affiliation":[{"name":"Diagnostic Center for Sonography (H.N., M.M., H.I., M.N., S.Y., M.G., Y.S., S.K., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-9093","authenticated-orcid":true,"given":"Michito","family":"Murayama","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Sonography (H.N., M.M., H.I., M.N., S.Y., M.G., Y.S., S.K., T.T.), Hokkaido University Hospital, Sapporo, Japan."},{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences (M.M., S.K.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-8260","authenticated-orcid":true,"given":"Hiroyuki","family":"Iwano","sequence":"additional","affiliation":[{"name":"Diagnostic Center for Sonography (H.N., M.M., H.I., M.N., S.Y., M.G., Y.S., S.K., T.T.), Hokkaido University Hospital, Sapporo, Japan."},{"name":"Division of Cardiology, Teine Keijinkai Hospital, Sapporo, Japan (H.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2305-0049","authenticated-orcid":true,"given":"Nobuyuki","family":"Kagiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan (N.K., Y.N., Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan (N.K., Y.N., Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3551-7976","authenticated-orcid":true,"given":"Yuka","family":"Akama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan (N.K., Y.N., Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Toki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory (M.T.), The Sakakibara Heart Institute of Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Nursing (S.T.), The Sakakibara Heart Institute of Okayama, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-3446","authenticated-orcid":true,"given":"Taiji","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Japan (T.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-8441","authenticated-orcid":true,"given":"Yasuyuki","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nakabachi","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine (H.N., M.N., S.Y., M.G., C.W., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-4499","authenticated-orcid":true,"given":"Shinobu","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine (H.N., M.N., S.Y., M.G., C.W., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Goto","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine (H.N., M.N., S.Y., M.G., C.W., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukino","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5043-2464","authenticated-orcid":true,"given":"Suguru","family":"Ishizaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-4091","authenticated-orcid":true,"given":"Ko","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-3223","authenticated-orcid":true,"given":"Yoji","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7290-151X","authenticated-orcid":true,"given":"Hiroyuki","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5718-9540","authenticated-orcid":true,"given":"Sanae","family":"Kaga","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences (M.M., S.K.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine (H.N., M.N., S.Y., M.G., C.W., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-8767","authenticated-orcid":true,"given":"Kiwamu","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-0608","authenticated-orcid":true,"given":"Toshiyuki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Teshima","sequence":"additional","affiliation":[{"name":"Division of Laboratory and Transfusion Medicine (H.N., M.N., S.Y., M.G., C.W., T.T.), Hokkaido University Hospital, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-4967","authenticated-orcid":true,"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine (Y.C., S.I., K.M., Y.T., H.A., K.N., K.K., T.N., T.A.), Hokkaido University, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(09)60443-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30968-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.02.013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab208"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2023.04.016"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.06.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.9.2138"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(98)00978-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0894-7317(99)70145-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.81.1.260"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90416-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.653576"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0999"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-022-01224-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(96)00238-x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.959"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15216"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.083170"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20456"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1332-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.02.004"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.124.017134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:10:32Z","timestamp":1748553032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.124.017134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1161\/CIRCIMAGING.124.017134"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.124.017134","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}