{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:45:25Z","timestamp":1773387925221,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"abstract":"\n BACKGROUND:<\/jats:title>\n \n Infective endocarditis (IE) can be challenging to diagnose. Positron emission tomography\/computed tomography (PET\/CT) with 2-deoxy-2-[\n 18<\/jats:sup>\n F]-fluoro-\n d<\/jats:sc>\n -glucose ([\n 18<\/jats:sup>\n F]FDG) is recommended as a diagnostic tool in the guidelines, but holds limitations. The aim of this study was to compare the tracer uptake between the novel [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE, which has low cardiac uptake and does not require fasting or dietary restrictions, and [\n 18<\/jats:sup>\n F]FDG in patients with IE and examine the sensitivity and specificity.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n The CuDOS study (Cu-Dotatate Positron Emissions Tomography in Infective Endocarditis) was a prospective study including 20 patients with IE (10 with prosthetic valve endocarditis and 10 with native valve endocarditis) and 20 controls. All participants underwent [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE and [\n 18<\/jats:sup>\n F]FDG PET\/CT. Scans were read blinded to clinical data. Tracer uptakes were measured as maximum standardized uptake values in each heart valve. Differences were tested with Wilcoxon rank tests.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The median age of the cases and controls was 68 years (interquartile range [IQR], 55.0\u201375.5) and 61 years (IQR, 57.0\u201369.5), respectively. [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR]) in patients with IE was higher than in controls (2.34 [1.40\u20133.23] versus 1.44 [1.21\u20131.60];\n P<\/jats:italic>\n =0.008), although this difference was mainly driven by prosthetic valve endocarditis cases (3.23 [2.02\u20133.86];\n P<\/jats:italic>\n <0.001) and not between native valve endocarditis cases and controls (1.51 [1.23\u20132.58];\n P<\/jats:italic>\n =0.428). The sensitivity of [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE and [\n 18<\/jats:sup>\n F]FDG PET\/CT in 20 cases versus 20 controls were equal, and the specificity was 90% and 75%, respectively. The analysis of prosthetic valve endocarditis versus the 20 controls showed equal sensitivity (80%), and a specificity of 90% and 75%, respectively (\n P<\/jats:italic>\n =0.38). In addition, a greater proportion of scans achieved diagnostic certainty with [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE PET\/CT compared with [\n 18<\/jats:sup>\n F]FDG PET\/CT for native valve endocarditis, prosthetic valve endocarditis, and controls.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE PET\/CT showed uptake in the infected valve in patients with IE, and has major advantage as it does not require any preparation compared with [\n 18<\/jats:sup>\n F]FDG. [\n 64<\/jats:sup>\n Cu]Cu-DOTATATE had a numerically higher specificity than [\n 18<\/jats:sup>\n F]FDG, although the difference was not statistically significant. Both tracers were limited in the detection of native valve endocarditis.\n <\/jats:p>\n <\/jats:sec>\n \n REGISTRATION:<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT05432427.\n www.clinicaltrialsregister.eu<\/jats:ext-link>\n ; Unique identifier: 2021-005501-27.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circimaging.124.017156","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T10:01:51Z","timestamp":1738663311000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["First-In-Human Study of [\n 64<\/sup>\n Cu]Cu-DOTATATE PET\/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [\n 18<\/sup>\n F]FDG"],"prefix":"10.1161","clinical-trial-number":[{"clinical-trial-number":"nct05432427","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-6777","authenticated-orcid":true,"given":"Katra","family":"Hadji-Turdeghal","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen (K.H.-T., H.B., L.K., E.L.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-6534","authenticated-orcid":true,"given":"Marie \u00d8bro","family":"Fosb\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen (M.O.F., P.H., J.L., H.H.J., A.K.\u00e6r, R.S.R.)"},{"name":"Cluster for Molecular Imaging, Copenhagen University Hospital\u2014Rigshospitalet & Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark(M.O.F., A.K.\u00e6r, R.S.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-6012","authenticated-orcid":true,"given":"Philip","family":"Hasbak","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen (M.O.F., P.H., J.L., H.H.J., A.K.\u00e6r, R.S.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1809","authenticated-orcid":true,"given":"Johan","family":"L\u00f6fgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen (M.O.F., P.H., J.L., H.H.J., A.K.\u00e6r, R.S.R.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-763X","authenticated-orcid":true,"given":"Ida","family":"Bull Rasmussen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen, Copenhagen, Denmark (I.B.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":true,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen (K.H.-T., H.B., L.K., E.L.F.)"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark (H.B., K.I., L.K., R.S.R., E.L.F.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-8487","authenticated-orcid":true,"given":"Kasper","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark (H.B., K.I., L.K., R.S.R., E.L.F.)"},{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark (K.I.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-9193","authenticated-orcid":true,"given":"Niels Eske","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zealand University Hospital, Roskilde, Denmark (N.E.B.)."},{"name":"Clinical Institutes, Copenhagen and Aalborg Universities, Aalborg, Denmark (N.E.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-9736","authenticated-orcid":true,"given":"Christian H.","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark (C.H.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Tuxen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bispebjerg and Frederiksberg 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