{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:59:05Z","timestamp":1792814345745,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Current guidelines recommend implantable cardioverter defibrillators for the primary prevention of sudden cardiac death (SCD) in patients with dilated cardiomyopathy with left ventricular ejection fraction (LVEF)\u226435%. However, its effectiveness is hindered by the inability to reliably discriminate between the risk of SCD and competing death of heart failure deterioration, thereby limiting its clinical utility. We aimed to refine the SCD risk stratification model based on cardiac magnetic resonance imaging for patients with dilated cardiomyopathy with LVEF\u226435%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A total of 1272 patients with dilated cardiomyopathy with LVEF\u226435% who underwent cardiac magnetic resonance imaging were consecutively enrolled in this study. The primary end point is a composite of SCD or aborted SCD and the second end point is a composite of heart failure death and heart transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Over a median follow-up of 86.3 months, 101 patients reached the primary end point. In the adjusted analysis, age (hazard ratio [HR], 1.02 [95% CI, 1.01\u20131.04];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006) years, a family history of SCD (HR, 2.00 [95% CI, 1.01\u20133.98];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.05), NT-proBNP (N-terminal pro-B-type natriuretic peptide) (HR, 2.02 [95% CI, 1.18\u20133.44];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), LVEF (per 5% HR, 0.79 [95% CI, 0.66\u20130.95];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.01), and late gadolinium enhancement\u22657.5% (HR, 4.11[95% CI, 2.72\u20136.21];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) were associated with SCD or aborted SCD. Left atrial volume index\u226568.3 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      was an independent predictor of the secondary end point (adjusted HR, 1.65 [95% CI, 1.13\u20132.40];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009). Compared with late gadolinium enhancement&lt;7.5%, patients with late gadolinium enhancement\u22657.5% and LVEF\u226420% had a 7.12-fold higher risk of experiencing SCD events in competing Cox analysis (annual event rate, 4.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Patients with dilated cardiomyopathy with late gadolinium enhancement\u22657.5% were at heightened risk of SCD events, which can be used for risk assessment. Risk stratifications for SCD, combining clinical and cardiac magnetic resonance imaging may potentially guide decision-making for implantable cardioverter defibrillator therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.124.017246","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T14:00:51Z","timestamp":1742306451000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Prognosis and Risk Stratification in Dilated Cardiomyopathy With LVEF\u226435%: Cardiac MRI Insights for Better Outcomes"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9766-860X","authenticated-orcid":true,"given":"Di","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0750-5779","authenticated-orcid":true,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8898-6078","authenticated-orcid":true,"given":"Weichun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography (W.W.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."},{"name":"Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (M.L., W. W., X.S)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-5514","authenticated-orcid":true,"given":"Baiyan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-4489","authenticated-orcid":true,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-5145","authenticated-orcid":true,"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-7921","authenticated-orcid":true,"given":"Yining","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2382-8869","authenticated-orcid":true,"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Heart Failure (Y.Z.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-4332","authenticated-orcid":true,"given":"Guanshu","family":"Liu","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD (G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine (X.S.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."},{"name":"Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (M.L., W. W., X.S)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3385-1242","authenticated-orcid":true,"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (Q.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-6157","authenticated-orcid":true,"given":"Zhongzhao","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Life and Health Science, Fuyao University of Science and Technology, Fujian, China (Z.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Sirajuddin","sequence":"additional","affiliation":[{"name":"National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-1466","authenticated-orcid":true,"given":"Andrew E.","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine and Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah, USA (A.E.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-318X","authenticated-orcid":true,"given":"Minjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging (D.Z., L.Z., S.L., B.Z., J.X., W.Y., J.H., Y.W., S.Z., M.L.), Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."},{"name":"Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (M.L., W. W., X.S)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.07.023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608029"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033088"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609758"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.687103"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.027134"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad194"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.030"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.213059"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft019"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27160"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab117"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.05.013"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.11.015"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-019-0589-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180199"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4909"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12126"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.5654"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001470100339"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028829"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.01.003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1363"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2593"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs337"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.967828"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi555"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.584102"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.001"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.124.017246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:37:26Z","timestamp":1773772646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.124.017246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1161\/CIRCIMAGING.124.017246"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.124.017246","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}