{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:30:15Z","timestamp":1792132215308,"version":"4.4.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Imaging markers of atherosclerotic inflammation are needed to enhance cardiovascular risk assessment and evaluate the impact of therapies. We sought to test the hypothesis that treatments impacting arterial inflammation can be evaluated using a simplified measure of periaortic fat attenuation (FA) assessed on noncontrast, nongated computed tomography of the descending thoracic aorta.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Measurements were performed on\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose positron emission tomography\/computed tomography images from a double-blind, randomized trial conducted between 2008 and 2009 that assessed the impact of statin therapy on arterial inflammation. Periaortic adipose tissue quantification was performed on the chest computed tomography images over a 10 cm portion of the descending aorta. FA was determined as the mean attenuation of the entire volume of delineated periaortic fat. Arterial inflammation (aorta) and leukopoietic activity (bone marrow and spleen) were assessed by measuring standardized uptake values on\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose positron emission tomography images. Baseline relationships and changes from baseline to 12 weeks were assessed. All models evaluating FA were adjusted for baseline kilovoltage peak.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Sixty subjects (79.9% men, mean age 60\u00b18.9 years) with risk factors or established atherosclerosis (32 randomized to atorvastatin 10 mg, 28 randomized to atorvastatin 80 mg) were studied. On average, it took 88\u00b117 seconds to assess FA per subject. At baseline, FA correlated with leukopoietic activity (\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.412;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.021 and\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.442;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.013, for bone marrow and spleen, respectively). Furthermore, FA correlated with aortic inflammation assessed on\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose positron emission tomography as quintiles (\n              <jats:italic toggle=\"yes\">r<\/jats:italic>\n              =0.274;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.043). Moreover, high dose (versus low dose) atorvastatin was associated with a significant reduction in FA after 12 weeks (standardized \u03b2=\u22120.603;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.010) after adjustment for baseline FA, kilovoltage peak, and prior statin use.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Periaortic FA is a marker of atherosclerotic inflammation that can be easily measured on nongated, nonenhanced chest computed tomography images and be used to provide insights into the impact of therapies on atherosclerotic inflammation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.124.017248","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:00:30Z","timestamp":1747198830000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Periaortic Fat Attenuation on Nongated Noncontrast Chest CT Images to Assess Changes in Arterial Inflammation: Impact of Atorvastatin"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-5568","authenticated-orcid":true,"given":"Guillaume","family":"Goudot","sequence":"first","affiliation":[{"name":"Cardiology Division (G.G., S.A., M.T.O., W.A., T.Z.A., M.T.L., B.F., A.T.), Massachusetts General Hospital and Harvard Medical School, Boston."},{"name":"Cardiovascular Imaging Research Center (G.G., S.A., M.T.O., W.A., T.Z.A., M.T.L., B.F., A.T.), Massachusetts General Hospital and Harvard Medical School, Boston."},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U970, Vascular Medicine Department, H\u00f4pital Europ\u00e9en Georges-Pompidou, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), France (G.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-8881","authenticated-orcid":true,"given":"Shady","family":"Abohashem","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.G., S.A., M.T.O., W.A., T.Z.A., M.T.L., B.F., A.T.), Massachusetts General Hospital and Harvard Medical School, Boston."},{"name":"Cardiovascular Imaging Research Center (G.G., S.A., M.T.O., W.A., T.Z.A., M.T.L., B.F., A.T.), Massachusetts General Hospital and Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-1718","authenticated-orcid":true,"given":"Michael T.","family":"Osborne","sequence":"additional","affiliation":[{"name":"Cardiology Division (G.G., S.A., M.T.O., W.A., T.Z.A., M.T.L., B.F., A.T.), 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