{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:53:11Z","timestamp":1788691991245,"version":"build-2803163510"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions were used to evaluate the relationship between diastolic function measures and mortality in the DMD cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Patients with DMD had significantly smaller stature and ventricular volumes than healthy control patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). They had lower baseline LV ejection fraction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), though most had normal systolic function. When adjusted for age, sex, heart rate, body surface area, and LV end-diastolic volume, patients with DMD had slower peak filling rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and peak ejection rates (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), as well as slower time to peak ventricular ejection rate (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.011). When adjusted for heart rate, a lower peak ventricular ejection rate (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.007) and peak filling rate (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.033), normalized to LV end-diastolic volume, were associated with mortality in patients with DMD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Patients with DMD have significantly different baseline CMR filling and ejection indices compared with controls. Some filling indices are associated with mortality and may be useful prognostic measures. Further research is needed in larger cohorts to determine the prognostic value of these differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.124.017287","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:01:07Z","timestamp":1733288467000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-5385","authenticated-orcid":true,"given":"Joseph R.","family":"Starnes","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6851-2588","authenticated-orcid":true,"given":"Jeffrey G.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-5417","authenticated-orcid":true,"given":"Kristen","family":"George-Durrett","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-1541","authenticated-orcid":true,"given":"Kimberly","family":"Crum","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN (J.R.S., J.G.W., K.G.-D., K.C., C.C.H., J.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-9038","authenticated-orcid":true,"given":"M. Jay","family":"Campbell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC (M.J.C., J.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn","family":"Gambetta","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL (K.G., N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-5227","authenticated-orcid":true,"given":"Kan N.","family":"Hor","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Nationwide Children\u2019s Hospital, Ohio State University, Columbus (K.N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4743-2313","authenticated-orcid":true,"given":"Nazia","family":"Husain","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, IL (K.G., N.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3254-1712","authenticated-orcid":true,"given":"Jennifer S.","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC (M.J.C., J.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-6569","authenticated-orcid":true,"suffix":"Jr","given":"Frank J.","family":"Raucci","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Children\u2019s Hospital of Richmond at Virginia Commonwealth University (F.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-1960","authenticated-orcid":true,"given":"Brian D.","family":"Soriano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Seattle Children\u2019s Hospital, WA (B.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-5735","authenticated-orcid":true,"given":"Christopher F.","family":"Spurney","sequence":"additional","affiliation":[{"name":"Children\u2019s National Heart Institute, Children\u2019s National Hospital, Washington, DC (C.F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-4641","authenticated-orcid":true,"given":"Larry W.","family":"Markham","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health and Indiana University School of Medicine, Indianapolis 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