{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:22:58Z","timestamp":1789096978484,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>\n              Myocardial perfusion imaging by positron emission tomography (PET) is recommended as a first-line test in stable patients with chest pain symptoms and as a selective second-line test after an abnormal coronary computed tomography angiography (CTA). It is, however, unknown whether the use of Rubidium-82 (\n              <jats:sup>82<\/jats:sup>\n              Rb) versus [\n              <jats:sup>15<\/jats:sup>\n              O]H\n              <jats:sub>2<\/jats:sub>\n              O (\n              <jats:sup>15<\/jats:sup>\n              O-water) affects the diagnostic performance in coronary artery disease (CAD). The aim of this study was to compare\n              <jats:sup>82<\/jats:sup>\n              Rb-PET versus\n              <jats:sup>15<\/jats:sup>\n              O-water-PET head-to-head for diagnosing obstructive CAD.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              The study included consecutive patients (n=1000) referred for CTA with symptoms suggestive of obstructive CAD. Patients with suspected stenosis based on CTA were referred for both\n              <jats:sup>82<\/jats:sup>\n              Rb-PET,\n              <jats:sup>15<\/jats:sup>\n              O-water-PET, and subsequently invasive coronary angiography (ICA), including 3-vessel fractional flow reserve and coronary flow reserve measurements.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              In total, 196\/270 (73%) patients with suspected stenosis on CTA completed\n              <jats:sup>82<\/jats:sup>\n              Rb-PET,\n              <jats:sup>15<\/jats:sup>\n              O-water-PET, and ICA. Myocardial blood flow measurements from\n              <jats:sup>82<\/jats:sup>\n              Rb-PET and\n              <jats:sup>15<\/jats:sup>\n              O-water-PET correlated strongly at rest (\u03c1, 0.62\u20130.69) but only moderately during hyperemia (\u03c1, 0.41\u20130.59). Only weak correlations were demonstrated between myocardial blood flow reserve by both PET tracers compared with ICA coronary flow reserve (\u03c1, 0.11\u20130.38). Hemodynamically obstructive CAD defined as ICA fractional flow reserve \u22640.80, was identified in 86\/196 (44%) patients. Using predefined cutoffs, the diagnostic accuracies of\n              <jats:sup>82<\/jats:sup>\n              Rb-PET versus\n              <jats:sup>15<\/jats:sup>\n              O-water-PET were similar (sensitivity 69% [58\u201378%] versus 71% [60\u201380%],\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.59; specificity 85% [76\u201391%] versus 77% [68\u201385%],\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.12). Using ICA diameter stenoses &gt;70% as a reference, only 48\/196 (24%) patients had anatomically severe CAD, and\n              <jats:sup>82<\/jats:sup>\n              Rb-PET and\n              <jats:sup>15<\/jats:sup>\n              O-water-PET sensitivities increased to &gt;85%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>\n              For detection of obstructive CAD by PET myocardial perfusion imaging,\n              <jats:sup>82<\/jats:sup>\n              Rb versus\n              <jats:sup>15<\/jats:sup>\n              O-water have similar diagnostic performance.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT04707859.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circimaging.124.017479","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T10:39:58Z","timestamp":1743676798000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Myocardial Perfusion Imaging With PET: A Head-to-Head Comparison of\n            <sup>82<\/sup>\n            Rubidium Versus\n            <sup>15<\/sup>\n            O-water Tracers Using Invasive Coronary Measurements as Reference"],"prefix":"10.1161","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct04707859","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-3681","authenticated-orcid":true,"given":"Simon","family":"Winther","sequence":"first","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laust Dupont","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Department of Cardiology, Aalborg University Hospital, Denmark (L.D.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-5477","authenticated-orcid":true,"given":"Salma Raghad","family":"Karim","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Cardiology (S.R.K., J.W., R.V.J., E.H.C.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-0844","authenticated-orcid":true,"given":"Jelmer","family":"Westra","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.R.K., J.W., R.V.J., E.H.C.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-3926","authenticated-orcid":true,"given":"Jonathan N\u00f8rtoft","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-5600","authenticated-orcid":true,"given":"Jacob Hartmann","family":"S\u00f8by","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian B\u00f8gild","family":"Lomstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7150-7704","authenticated-orcid":true,"given":"Morten","family":"W\u00fcrtz","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Munch","family":"Sundb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Cardiology (S.W., L.D.R., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., M.B.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2898-6988","authenticated-orcid":true,"given":"June Anita","family":"Ejlersen","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Clinical Physiology, Viborg Hospital, Denmark (J.A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine (J.M.), G\u00f8dstrup Hospital, Herning, Denmark."},{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-7046","authenticated-orcid":true,"given":"Lars Poulsen","family":"Tolbod","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Nuclear Medicine (L.P.T., M.A.M., L.C.G.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Maare","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark (H.M.S., N.C.L.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaj Christopher Lyng","family":"Hansson","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Cardiology, Regional Hospital Central Jutland, Viborg, Denmark (H.M.S., N.C.L.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-8543","authenticated-orcid":true,"given":"Mette","family":"Nyegaard","sequence":"additional","affiliation":[{"name":"Department of Health, Science and Technology, Aalborg University, Denmark (M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-5275","authenticated-orcid":true,"given":"Rebekka Vibjerg","family":"Jensen","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Cardiology (S.R.K., J.W., R.V.J., E.H.C.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8002-6086","authenticated-orcid":true,"given":"Michael Alle","family":"Madsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Nuclear Medicine (L.P.T., M.A.M., L.C.G.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-4862","authenticated-orcid":true,"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., E.H.C., L.C.G., M.B.)."},{"name":"Department of Cardiology (S.R.K., J.W., R.V.J., E.H.C.), Aarhus University Hospital, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-1305","authenticated-orcid":true,"given":"Lars Christian","family":"Gormsen","sequence":"additional","affiliation":[{"name":"Institute of Clinical medicine, Aarhus University, Denmark (S.W., S.R.K., J.N.D., J.H.S., L.N., F.B.L., M.W., J.M.S., J.A.E., J.M., L.P.T., H.M.S., N.C.L.H., R.V.J., M.A.M., 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Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.124.017479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T18:00:46Z","timestamp":1750183246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.124.017479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1161\/CIRCIMAGING.124.017479"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.124.017479","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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