{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:44:50Z","timestamp":1787103890459,"version":"build-2736575974"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Psychosocial stress is linked to the development of cardiovascular disease, with a more pronounced impact in female participants. This study investigates sex differences in the association between perceived stress and myocardial tissue characteristics, as assessed by cardiovascular magnetic resonance imaging, and evaluates the contribution of psychosocial burden, including caregiving and perceived social standing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This study included 219 participants (53.9% females; mean age, 54.4\u00b111.0 years) without overt cardiovascular disease, drawn from a prospective repository. Participants completed the perceived stress scale and cardiovascular magnetic resonance with native T1 and T2 mappings. Psychosocial variables included family caregiving responsibilities and perceived emotional support. The study investigated associations between perceived stress scale scores, and native T1 and T2 mapping sequences and assessed sex differences and psychosocial burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      High-stress female participants had significantly longer T1 times than low-stress female participants in both healthy and at-risk groups and longer T2 times in the at-risk group. No significant differences were observed in male participants. Perceived stress scale scores significantly predicted T1 values in female participants (95% CI, 0.088\u20133.517;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.040) but not in male participants (94% CI, \u22120.687 to 2.139;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.310). In multivariable analysis, caregiving burden and perceived emotional support were independent predictors of T1 in female participants (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.035, respectively) but not in male participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Psychosocial stress was associated with early subclinical myocardial changes in female participants but not in male participants, suggesting sex-specific pathways linking stress to early myocardial remodeling. These findings support the integration of psychosocial factors into cardiovascular risk assessment for female individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.124.017667","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:04:53Z","timestamp":1760000693000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Sex Differences in the Relationship Between Psychosocial Stress and Myocardial Tissue Characteristics: A CMR Imaging Study"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6573-497X","authenticated-orcid":true,"given":"Mayssa","family":"Moukarzel","sequence":"first","affiliation":[{"name":"Department of Medicine and Health Sciences (M.M., K.S., M.G.F., J.M.L.), McGill University, Montreal, QC, Canada."},{"name":"School of Medicine, Lebanese American University, Beirut (M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian","family":"Soroush","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences (M.M., K.S., M.G.F., J.M.L.), McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience (Y.Z.), McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5497-5140","authenticated-orcid":true,"given":"Jean-Philippe","family":"Gouin","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Concordia, Montreal, QC, Canada (J.-P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1204-5647","authenticated-orcid":true,"given":"Matthias G.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences (M.M., K.S., M.G.F., J.M.L.), McGill University, Montreal, QC, Canada."},{"name":"Department of Diagnostic Radiology (M.G.F.), McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-0788","authenticated-orcid":true,"given":"Judy M.","family":"Luu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences (M.M., K.S., M.G.F., J.M.L.), McGill University, Montreal, QC, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00684-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-031912-114452"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.05.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx324"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309154"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23068"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.03.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-022-01046-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.23.3008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01696"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02031"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00316"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00244.2020"},{"key":"e_1_3_3_16_2","first-page":"99","article-title":"The relationship of stress and blood pressure effectors.","volume":"19","author":"Ayada C","year":"2015","unstructured":"Ayada C, Toru U, Korkut Y. The relationship of stress and blood pressure effectors. Hippokratia. 2015;19:99\u2013108. Available at https:\/\/pubmed.ncbi.nlm.nih.gov\/27418756\/","journal-title":"Hippokratia"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.024"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00666-4"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.072"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0028586"},{"key":"e_1_3_3_21_2","unstructured":"Cohen S Williamson GM. Perceived stress in a probability sample of the United States. In: Spacapan S Oskamp S eds. The Social Psychology of Health: The Claremont Symposium on Applied Social Psychology. Newbury Park CA: Sage; 1988:31\u201367."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/smi.3285"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02885-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2197"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00819-z"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/74.8.777"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1108"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcop.22886"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-023-00974-5"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0389-8"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00049"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318159"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.06.011"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-56"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02424-6"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2112-8"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011866"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l1255"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.067"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03697"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49793-8"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.014"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002188"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-013-0166-4"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028595"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv001"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-3797(02)00582-2"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2023.2286296"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45836"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1085914"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.124.017667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T19:00:21Z","timestamp":1763492421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.124.017667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1161\/CIRCIMAGING.124.017667"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.124.017667","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2024-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}