{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:31:13Z","timestamp":1777501873946,"version":"3.51.4"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The impact of lipid core burden index (LCBI) after percutaneous coronary intervention (PCI) in the stented segment assessed by intracoronary near-infrared spectroscopy on the outcomes remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              In this prospective observational study, we aimed to assess the impact of post-PCI LCBI on late lumen loss and clinical outcomes. Post-PCI intracoronary near-infrared spectroscopy imaging was performed in the stented segment after PCI. Patients were categorized into 2 groups based on the post-PCI\n              <jats:sub>max<\/jats:sub>\n              LCBI\n              <jats:sub>4mm<\/jats:sub>\n              with a cut-off value of 200. Angiographic and clinical outcomes were compared at 12 months. The primary end point was angiographic late lumen loss. The secondary end point was target lesion failure (composite of cardiovascular death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and major adverse cardiac and cerebrovascular events (composite of cardiac death, myocardial infarction, any repeat revascularization, and stroke).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 228 patients with 278 target lesions were followed up for 1 year. One-year follow-up angiography was performed on 198 lesions in 163 patients. Follow-up quantitative coronary angiography revealed that stented segments with post-PCI\n              <jats:sub>max<\/jats:sub>\n              LCBI\n              <jats:sub>4mm<\/jats:sub>\n              \u2265200 had higher late lumen loss compared with those with a post-PCI\n              <jats:sub>max<\/jats:sub>\n              LCBI\n              <jats:sub>4mm<\/jats:sub>\n              &lt;200 (mean, 0.503\u00b10.683 mm versus 0.115\u00b10.326 mm;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001; median, 0.250 mm versus 0.050 mm;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). Patients with post-PCI\n              <jats:sub>max<\/jats:sub>\n              LCBI\n              <jats:sub>4mm<\/jats:sub>\n              \u2265200 had a significantly higher 1-year cumulative incidence of both target lesion failure (6.9% versus 0.6%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.002) and major adverse cardiac and cerebrovascular events (15.1% versus 2.2%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Post-PCI LCBI assessed by intracoronary near-infrared spectroscopy-intravascular ultrasound was associated with late lumen loss as well as subsequent target lesion failure and major adverse cardiac and cerebrovascular events.<\/jats:p>\n          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Medicine, Hanyang University, Seoul, Republic of Korea (W.K., H.K., S.P., R.H., J.P., J.S., Y.L., Y.-H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7931-777X","authenticated-orcid":true,"given":"Jin-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea (W.K., H.K., S.P., R.H., J.P., J.S., Y.L., Y.-H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-6504","authenticated-orcid":true,"given":"Jinho","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea (W.K., H.K., S.P., R.H., J.P., J.S., Y.L., Y.-H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-3692","authenticated-orcid":true,"given":"Yonggu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea (W.K., H.K., S.P., R.H., J.P., J.S., Y.L., Y.-H.L.)."},{"name":"Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Republic of Korea (Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-7425","authenticated-orcid":true,"given":"Young-Hyo","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea (W.K., H.K., S.P., R.H., J.P., J.S., Y.L., 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