{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:59:58Z","timestamp":1790312398366,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Randomized trials of venous thrombolysis to prevent postthrombotic syndrome have produced mixed results. A method to identify patients most likely to benefit from interventional treatment is needed. This study evaluated a contrast-free, magnetic resonance-based multisequence thrombus imaging (MSTI) technique to characterize deep venous thrombi and predict susceptibility to thrombolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Venous thrombosis was induced in the inferior vena cava of BALB\/C mice (n=56, male), which were imaged up to 28 days postsurgery and 24 hours after systemic thrombolysis (Actilyse, 10 mg\/kg, IV). The prelysis MSTI protocol included 3-dimensional T1 mapping, 3-dimensional magnetization transfer, and 2-dimensional diffusion-weighted imaging. Thrombolysis was defined as successful if inferior vena cava blood flow increased by \u226550% compared with prelysis values. In a clinical cohort, 41 patients with acute iliofemoral deep venous thrombi underwent MSTI before catheter-directed thrombolysis. Imaging parameters were analyzed against postintervention outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      MSTI identified thrombi susceptible to thrombolysis in both mice and humans. In mice, lysed thrombi showed lower T1 (723 [667\u2013782] versus 874 [799\u20131000] ms;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and higher apparent diffusion coefficient values (1.02 [0.96\u20131.14] versus 0.78 [0.62\u20130.88]\u00d710\n                      <jats:sup>-<\/jats:sup>\n                      \u00b3 mm\u00b2\/s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) than nonlysable thrombi, with no difference in magnetization transfer. In patients, lysed thrombi demonstrated lower T1 (606 [543\u2013656] versus 765 [630\u2013909] ms;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), lower apparent diffusion coefficient (0.67 [0.5\u20131.1] versus 1.23 [0.69\u20131.74]\u00d710\n                      <jats:sup>-<\/jats:sup>\n                      \u00b3 mm\u00b2\/s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001), and similar magnetization transfer rates. Combining MSTI parameters optimized prediction, achieving 88% sensitivity and 97% specificity in mice, and 86% sensitivity and 91% specificity in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>MSTI enables noninvasive, contrast-free characterization of thrombus composition and predicts thrombolytic susceptibility. This technique has the potential to guide patient selection for invasive therapies and should be incorporated into future trials of venous thrombosis treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.125.018175","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:00:16Z","timestamp":1762160416000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Multiparametric Contrast-Free MRI Successfully Identifies Venous Thrombus Responsive to Lytic Therapy: From Mice to Humans"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5995-4488","authenticated-orcid":true,"given":"Justinas","family":"Silickas","sequence":"first","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine &amp; Sciences (J.S., A.S., B.M., A.S.P., S.B.), Kings College London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine &amp; Sciences (J.S., A.S., B.M., A.S.P., S.B.), Kings College London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-5832","authenticated-orcid":true,"given":"Marcelo E.","family":"Andia","sequence":"additional","affiliation":[{"name":"Radiology Department, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago (M.E.A.)."},{"name":"Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile (M.E.A., R.M.B.)."},{"name":"Escuela de Ingenier\u00eda (M.E.A.), Pontificia Universidad Cat\u00f3lica de Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-2509","authenticated-orcid":true,"given":"Ren\u00e9 M.","family":"Botnar","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, Research Department of Cardiovascular Imaging (R.M.B., N.K., P.S.), Kings College London, UK."},{"name":"Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile (M.E.A., R.M.B.)."},{"name":"Institute for Biological and Medical Engineering (R.M.B), Pontificia Universidad Cat\u00f3lica de Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-5768","authenticated-orcid":true,"given":"Bijan","family":"Modarai","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine &amp; Sciences (J.S., A.S., B.M., A.S.P., S.B.), Kings College London, UK."},{"name":"Department of Vascular Surgery (B.M., A.S.P., S.B., P.S.), Guy\u2019s and St. Thomas\u2019 NHS Trust, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan","family":"Karunanithy","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, Research Department of Cardiovascular Imaging (R.M.B., N.K., P.S.), Kings College London, UK."},{"name":"Department of Interventional Radiology, (N.K.), Guy\u2019s and St. Thomas\u2019 NHS Trust, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish S.","family":"Patel","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine &amp; Sciences (J.S., A.S., B.M., A.S.P., S.B.), Kings College London, UK."},{"name":"Department of Vascular Surgery (B.M., A.S.P., S.B., P.S.), Guy\u2019s and St. Thomas\u2019 NHS Trust, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Black","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Medicine &amp; 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