{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:43Z","timestamp":1792511023618,"version":"4.5.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Sudden cardiac death due to primary arrhythmia is a leading cause of mortality in athletes, predominantly affecting older male athletes. Myocardial fibrosis is strongly associated with arrhythmogenesis in nonischemic cardiomyopathy, but its clinical significance in asymptomatic endurance athletes is unknown. We aimed to investigate whether myocardial fibrosis on cardiovascular magnetic resonance in asymptomatic veteran male athletes was associated with incident ventricular arrhythmia on long-term implantable loop recorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Prospective observational cohort study involving 106 asymptomatic male competitive cyclists\/triathletes (aged \u226550 years) who undertook \u226510 h\/wk of exercise for \u226515 years. Exclusion criteria were any preexisting cardiovascular disease. Participants underwent clinical assessment, stress-perfusion late gadolinium enhancement-cardiovascular magnetic resonance, exercise testing, and implantable loop recorder implantation to detect ventricular arrhythmia. Athletes were followed up for the primary end point of incident ventricular arrhythmia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 50\/106 (47.2%) athletes had focal myocardial fibrosis (all nonischemic distribution) on cardiovascular magnetic resonance predominantly affecting the basal inferolateral left ventricular segment. During follow-up (median 720 days), 23\/106 (21.7%) athletes experienced \u22651 ventricular arrhythmic episode; 3\/106 (2.8%) sustained ventricular tachycardia, and 20\/106 (18.9%) nonsustained ventricular tachycardia. Myocardial fibrosis (hazard ratio, 4.7 [95% CI, 1.8\u201312.8];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002) and greater left ventricular end-diastolic volume indexed (hazard ratio, 1.4 [95% CI, 1.1\u20131.9];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.02) were associated with an increased risk of incident ventricular arrhythmia, but right ventricular insertion point late gadolinium enhancement was not (hazard ratio, 1.7 [95% CI 0.6\u20135.1];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.32). Myocardial fibrosis remained predictive after adjusting for left ventricular end-diastolic volume indexed (hazard ratio, 4.7 [95% CI, 1.7\u201312.7];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In male veteran endurance athletes, myocardial fibrosis was independently associated with the onset of ventricular arrhythmia, even after adjusting for left ventricular dilatation. Right ventricular insertion point late gadolinium enhancement was not associated with ventricular arrhythmia. Further studies are needed to establish whether myocardial fibrosis itself is arrhythmogenic or a marker of an underlying cardiomyopathic process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.125.018470","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T23:01:27Z","timestamp":1752793287000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Ventricular Arrhythmia and Cardiac Fibrosis in Endurance Experienced Athletes (VENTOUX)"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-5708","authenticated-orcid":true,"given":"Wasim","family":"Javed","sequence":"first","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Botis","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-8470","authenticated-orcid":true,"given":"Ze Min","family":"Goh","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubien","family":"Shabi","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Brown","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Tomoaia","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."},{"name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania (R.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2441-1528","authenticated-orcid":true,"given":"Maryum","family":"Farooq","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-7102","authenticated-orcid":true,"given":"Eylem","family":"Levelt","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute and University of Melbourne, Australia (E.L., J.P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Graham","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-191X","authenticated-orcid":true,"given":"John","family":"Gierula","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds\/Leeds Teaching Hospitals National Health Service Trust, United Kingdom (W.J., I.B., Z.M.G., M.S., B.B., R.T., M.F., L.G., J.G., J.P.G., S.P., P.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-6070","authenticated-orcid":true,"given":"Peter","family":"Kellman","sequence":"additional","affiliation":[{"name":"National Institutes for Health, National Heart, Lung, and Blood Institute, Bethesda, MD 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