{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:26:17Z","timestamp":1784838377258,"version":"3.55.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Guidelines recommend 3-hour cardiac amyloid radionuclide imaging (CARI) for transthyretin amyloid cardiomyopathy. Citing rapid blood clearance of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-hydroxymethylene-diphosphonate (HMDP) and efficient laboratory throughput, 1-hour imaging is increasingly practiced despite limited supporting evidence. We sought to compare diagnostic performance and interpreter experience of 1-hour versus 3-hour HMDP-CARI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Consecutive patients with suspected transthyretin amyloid cardiomyopathy (n=114) underwent both 1-hour and 3-hour HMDP single photon emission computed tomography (CT)\/CT. Two cardiologist-radiologist reader teams, blinded to imaging timepoint (1 versus 3 hours), assessed overall interpretation, single photon emission CT\u2013based Perugini grade, interpretation difficulty, interpreter confidence, and need for CT-fused images for anatomic localization. Discordant, equivocal, and difficult cases were arbitrated by a third tie-breaking team. The myocardial-to-blood-pool radiotracer uptake ratio (3-dimensional Score) was measured as a surrogate of contrast resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Interinterpreter agreement was high at both time points (\u03ba\u22650.81), with more cases requiring arbitration at 3 hours versus 1 hour (22% versus 13%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.049). Overall interpretation and Perugini grades were concordant between time points in 111\/114 (97%) and 106\/114 (93%) patients, respectively. Three patients (3%) were negative at 1 hour but equivocal at 3 hours, all of which were clinically ruled out for transthyretin amyloid cardiomyopathy. Interpreter confidence was comparable at both timepoints (97% versus 95%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.317). Compared with 3-hour imaging, contrast resolution was inferior (lower 3-dimensional score,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and CT fusion was more frequently needed (57% versus 31%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) at 1-hour imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In a prospective, blinded comparison of 1-hour versus 3-hour HMDP-CARI, diagnostic performance and interpreter experience were similar, with readers requesting CT fusion more frequently at 1 hour to optimize myocardial-to-blood pool discrimination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.125.018745","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:00:11Z","timestamp":1765188011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Performance and Interpreter Experience of 1-Hour Versus 3-Hour\n                    <sup>99m<\/sup>\n                    Tc-HMDP Cardiac Amyloid Radionuclide Imaging: A Prospective, Blinded Comparison"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-1777","authenticated-orcid":true,"given":"Gregorio","family":"Tersalvi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9204-913X","authenticated-orcid":true,"given":"Patricia","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (P. Carey), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-8544","authenticated-orcid":true,"given":"Armin","family":"Garmany","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN (A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-0647","authenticated-orcid":true,"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences (C.G.S.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9405-6436","authenticated-orcid":true,"given":"Livia F.","family":"Kruger","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-5201","authenticated-orcid":true,"given":"Carrie B.","family":"Hruska","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-4072","authenticated-orcid":true,"given":"Geoffrey B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayan","family":"Jouni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Rodriguez-Porcel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6759-4032","authenticated-orcid":true,"given":"J. Wells","family":"Askew","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Bois","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."},{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-192X","authenticated-orcid":true,"given":"Kathleen A.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan S.","family":"Anavekar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."},{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-4440","authenticated-orcid":true,"given":"Martha","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-9512","authenticated-orcid":true,"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine (A.D.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-8712","authenticated-orcid":true,"given":"Panithaya","family":"Chareonthaitawee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Homb","sequence":"additional","affiliation":[{"name":"Department of Radiology (J.Z., F.J.M., L.F.K., C.B.H., G.B.J., J.P.B., N.S.A., A.C.H.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-3660","authenticated-orcid":true,"given":"Omar F.","family":"AbouEzzeddine","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (G.T., H.J., M.G.R.-P., J.W.A., J.P.B., K.A.Y., N.S.A., M.G., P. Chareonthaitawee, O.F.A.), Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0442"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.3070"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.073"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.123.265492"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-022-03059-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HCI.0000000000000029"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.010249"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-020-02139-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-023-03353-w"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-022-03021-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2024.102041"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.1781"},{"key":"e_1_3_3_15_2","first-page":"ehaf784.304","article-title":"Quantitative SPECT\/CT for diagnosis of transthyretin amyloid cardiomyopathy: a pathology-based study.","volume":"46","author":"Tersalvi G","year":"2025","unstructured":"Tersalvi G, Carey P, Garmany A, Scott CG, Homb AC, Hoffman AC, Zhang J, Davies DR, Askew JW, Dispenzieri A, et al. Quantitative SPECT\/CT for diagnosis of transthyretin amyloid cardiomyopathy: a pathology-based study. Eur Heart J. 2025;46:ehaf784.304.","journal-title":"Eur Heart J"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.10.015"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.125.018745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T19:00:37Z","timestamp":1768935637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.125.018745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1161\/CIRCIMAGING.125.018745"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.125.018745","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}