{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:59:24Z","timestamp":1788980364925,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Alternative indexation methods for left atrial volume (LAV) have been proposed to achieve better proportional scaling than the current standard body surface area indexation. However, there are limited data showing that these alternative indices provide long-term prognostic value in individuals with overweight or obesity. The aim of this study was to determine and compare the performance of various LAV indexation methods in predicting all-cause mortality in individuals with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We obtained data from the National Echocardiography Database Australia with linkage to mortality outcomes, selecting individuals with body mass index \u226525 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and valid LAV, height, weight, and left ventricular ejection fraction. We conducted receiver operating characteristic analyses, including area under the curve calculations, to compare the performance of 9 LAV indices in predicting all-cause mortality. In addition, we performed a survival analysis between LAV and all-cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 109\u2009543 individuals (age 60\u00b116 years, 47% women) were included. Indexing LAV by most methods performed similarly in predicting all-cause mortality, with areas under the curve between 0.60 and 0.62 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.05), except that LAV and LAV\/body mass index had the lowest area under the curve with 0.600 (0.595\u20130.604) and 0.602 (0.597\u20130.606). Indexation methods also performed similarly when separated by age, sex, or follow-up duration. A mortality threshold for LAV\/body surface area was observed at 34 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      , with no difference by sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Among patients with overweight or obesity, the majority of LAV indices performed similarly in predicting all-cause mortality. Our findings support the continued use of LA volume indexed to body surface area for prognosis in this population, and the current normal range of &lt;34 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/anzctr.org.au\/Default.aspx\">https:\/\/anzctr.org.au\/Default.aspx<\/jats:ext-link>\n                      ; Unique identifier: ACTRN12617001387314.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.125.019491","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:00:43Z","timestamp":1778749243000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Assessing Left Atrial Volume Indexation to Predict Mortality in Individuals With Overweight and Obesity"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"actrn12617001387314","registry":"10.18810\/anzctr"}],"author":[{"given":"Christine M.","family":"Madronio","sequence":"first","affiliation":[{"name":"Charles Perkins Centre (C.M.M., F.P., K.N.), The University of Sydney, New South Wales, Australia."},{"name":"Faculty of Medicine and Health (C.M.M., G.K.K.L., G.S., F.P.), The University of Sydney, New South Wales, Australia."},{"name":"Nepean Family Metabolic Health Service, Nepean Hospital, New South Wales, Australia (C.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.K.","family":"Low","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health (C.M.M., G.K.K.L., G.S., F.P.), The University of Sydney, New South Wales, Australia."},{"name":"Research Directorate, Nepean Hospital, Nepean Blue Mountains Local Health District, Kingswood, New South Wales, Australia (G.K.K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-4082","authenticated-orcid":true,"given":"Nishant","family":"Nundlall","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nepean Hospital, New South Wales, Australia (N.N., F.P., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-1103","authenticated-orcid":true,"given":"David","family":"Playford","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Notre Dame, Fremantle, Australia (D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-7119","authenticated-orcid":true,"given":"Geoffrey","family":"Strange","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health (C.M.M., G.K.K.L., G.S., F.P.), The University of Sydney, New South Wales, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-5470","authenticated-orcid":true,"given":"Faraz","family":"Pathan","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre (C.M.M., F.P., K.N.), The University of Sydney, New South Wales, Australia."},{"name":"Faculty of Medicine and Health (C.M.M., G.K.K.L., G.S., F.P.), The University of Sydney, New South Wales, Australia."},{"name":"Department of Cardiology, Nepean Hospital, New South Wales, Australia (N.N., F.P., K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-2565","authenticated-orcid":true,"given":"Kazuaki","family":"Negishi","sequence":"additional","affiliation":[{"name":"Charles Perkins Centre (C.M.M., F.P., K.N.), The University of Sydney, New South Wales, Australia."},{"name":"Department of Cardiology, Nepean Hospital, New South Wales, Australia (N.N., F.P., K.N.)."},{"name":"School of Clinical Medicine, University of New South Wales, Sydney, Australia (K.N.)."},{"name":"Department of Cardiology, Liverpool Hospital, New South Wales, Australia (K.N.)."},{"name":"The Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia (K.N.)."},{"name":"Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia (K.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.055"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006615"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.07.021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.034"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.04.043"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.05.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014609"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.02.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(16)31805-8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.05.014"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.01.019"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034646"},{"key":"e_1_3_3_15_2","volume-title":"National echo database Australia. NEDA","author":"NEDA","unstructured":"NEDA. National echo database Australia. NEDA. Accessed September 5, 2023. www.neda.net.au"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.07.001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2021.08.008"},{"key":"e_1_3_3_18_2","volume-title":"Body mass index (BMI) and waist measurement","author":"Department of Health Disability and Ageing","year":"2021","unstructured":"Department of Health Disability and Ageing. Body mass index (BMI) and waist measurement. Australian Government. Accessed 20 December. https:\/\/www.health.gov.au\/topics\/overweight-and-obesity\/bmi-and-waist. 2021"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.95.7.1837"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4097\/kja.21209"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.334"},{"key":"e_1_3_3_22_2","volume-title":"R: A language and environment for statistical computing. R Foundation for Statistical Computing","author":"R Core Team","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Accessed October 31, 2022. https:\/\/www.R-project.org\/"},{"key":"e_1_3_3_23_2","volume-title":"RStudio: integrated development environment for R","author":"RStudio Team","unstructured":"RStudio Team. RStudio: integrated development environment for R. Accessed July, 2022. https:\/\/www.rstudio.com\/"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46183-z"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-12-199812150-00005"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2011.00739.x"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.125.019491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T18:00:42Z","timestamp":1782064842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.125.019491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1161\/CIRCIMAGING.125.019491"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.125.019491","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}