{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:33:42Z","timestamp":1791650022374,"version":"4.3.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Cardiac amyloidosis (CA) is an underdiagnosed yet treatable cause of heart failure in which timely diagnosis is essential to initiate life-prolonging therapies. While artificial intelligence (AI)-based tools using transthoracic echocardiography (TTE), electrocardiography, or electronic health records have demonstrated promise for CA detection, most rely on single data sources. We aimed to evaluate whether integrating clinical, laboratory, and TTE biomarkers improves the performance of an existing TTE-based AI model for CA detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We developed and tested a combined AI echo-clinical model (AI-ECM) incorporating demographics, laboratory biomarkers, and TTE parameters into a previously validated TTE-only AI model (Us2.Ca). Model training and internal validation were performed using the Amyloidosis Imaging International Consortium, a global multiethnic registry comprised of 727 patients with CA and 316 controls, including 202 with suspected transthyretin-CA with negative diagnostic evaluation and 114 patients with biopsy-proven extracardiac light chain amyloidosis without cardiac involvement. Ground truth CA diagnosis was adjudicated per consensus criteria. AI-ECM and Us2.Ca performance was assessed using area under the curve, accuracy, sensitivity, and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In building the AI-ECM, feature importance analysis showed that having the Us2.Ca prediction scores, relative wall thickness, sex, and estimated glomerular filtration rate contributed most to performance. The AI-ECM demonstrated superior performance (area under the curve, 0.94; accuracy, 90%; sensitivity, 93%; specificity, 85%) compared with the Us2.Ca (area under the curve, 0.89; accuracy, 80%; sensitivity, 76%; specificity, 91%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006). While the Us2.Ca model classification was indeterminate in 9% of the cases, the AI-ECM allowed classification of all cases. The AI-ECM improved sensitivity for light chain-CA detection and maintained high accuracy across subtypes and control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>A multiparametric AI model integrating basic clinical, laboratory, and TTE data with the deep learning Us2.Ca improved performance for CA detection over Us2.Ca alone. This approach represents a step toward scalable, AI-guided precision diagnostics for CA in diverse populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circimaging.126.019610","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T09:01:03Z","timestamp":1779872463000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-4544","authenticated-orcid":true,"given":"Jeremy A.","family":"Slivnick","sequence":"first","affiliation":[{"name":"University of Chicago, IL (J.A.S., N.S., K.A., R.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-858X","authenticated-orcid":true,"given":"Sze Chi","family":"Lim","sequence":"additional","affiliation":[{"name":"Us2.AI, Singapore (S.C.L., M. Frost, C.L.S.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Randazzo","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Philadelphia (M.R., M.S.-C., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-5008","authenticated-orcid":true,"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Philadelphia (M.R., M.S.-C., A.V.)."},{"name":"Columbia University Irving Medical Center, New York (M.S.M., S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-3009","authenticated-orcid":true,"given":"Stephen","family":"Helmke","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York (M.S.M., S.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-9266","authenticated-orcid":true,"given":"Marielle","family":"Scherrer-Crosbie","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Philadelphia (M.R., M.S.-C., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azin","family":"Vakilpour","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania, Philadelphia (M.R., M.S.-C., A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-4106","authenticated-orcid":true,"given":"Karolina M.","family":"Zareba","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus (K.M.Z., A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-3523","authenticated-orcid":true,"given":"Akash","family":"Goyal","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus (K.M.Z., A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle (R.C., N.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9567-3551","authenticated-orcid":true,"given":"Nicole","family":"Nakamatsu","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle (R.C., N.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-5907","authenticated-orcid":true,"given":"Tetsuji","family":"Kitano","sequence":"additional","affiliation":[{"name":"Hospital of University of Occupational and Environmental Health, Japan (T.K., M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-1537","authenticated-orcid":true,"given":"Masaaki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Hospital of University of Occupational and Environmental Health, Japan (T.K., M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-3815","authenticated-orcid":true,"given":"Viviane Tiemi","family":"Hotta","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), Sao Paolo, Brazil (V.T.H., M.L.C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-5717","authenticated-orcid":true,"given":"Marcelo Luiz","family":"Campos Vieira","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor), Sao Paolo, Brazil (V.T.H., M.L.C.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5760-9227","authenticated-orcid":true,"given":"Pablo","family":"Elissamburu","sequence":"additional","affiliation":[{"name":"ICBA, Buenos Aires, Argentina (P.E., R.E.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E.","family":"Ronderos","sequence":"additional","affiliation":[{"name":"ICBA, Buenos Aires, Argentina (P.E., R.E.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-700X","authenticated-orcid":true,"given":"Aldo","family":"Prado","sequence":"additional","affiliation":[{"name":"Centro Privado de Cardiolog\u00eda, Tucuman, Argentina (A. Prado)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-6480","authenticated-orcid":true,"given":"Efstratios","family":"Koutroumpakis","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center, Houston (E.K., A.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-9591","authenticated-orcid":true,"given":"Anita","family":"Deswal","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center, Houston (E.K., A.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-8839","authenticated-orcid":true,"given":"Amit","family":"Pursnani","sequence":"additional","affiliation":[{"name":"Endeavor NorthShore, Evanston, IL (A. Pursnani)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0233-7881","authenticated-orcid":true,"given":"Nitasha","family":"Sarswat","sequence":"additional","affiliation":[{"name":"University of Chicago, IL (J.A.S., N.S., K.A., R.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Addetia","sequence":"additional","affiliation":[{"name":"University of Chicago, IL (J.A.S., N.S., K.A., R.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-8725","authenticated-orcid":true,"given":"Juan","family":"Cotella","sequence":"additional","affiliation":[{"name":"Altos de Salta Swiss Medical Group, Tucuman, Argentina (J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-4413","authenticated-orcid":true,"given":"Frederick L.","family":"Ruberg","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine, MA (F.L.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9760-4784","authenticated-orcid":true,"given":"Matthew","family":"Frost","sequence":"additional","affiliation":[{"name":"Us2.AI, Singapore (S.C.L., M. 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Accessed August 1, 2025. chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf25\/K250151.pdf"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.125.018991"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20381"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/hci.0000000000000029"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310704"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.10.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939785"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.05.002"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2022.1781"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005588"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.117143"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd12060221"}],"container-title":["Circulation: Cardiovascular Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCIMAGING.126.019610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T18:00:46Z","timestamp":1782064846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCIMAGING.126.019610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1161\/CIRCIMAGING.126.019610"],"URL":"https:\/\/doi.org\/10.1161\/circimaging.126.019610","relation":{},"ISSN":["1941-9651","1942-0080"],"issn-type":[{"value":"1941-9651","type":"print"},{"value":"1942-0080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}