{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:07:36Z","timestamp":1771232856855,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            There is evidence that endothelial coverage of drug-eluting stents might be delayed or absent, a risk factor for late thrombotic events. We studied the effects of different drug-polymer-device iterations on endothelium-dependent coronary vasomotion. Systemic markers of endothelial inflammation were correlated with coronary vasomotor changes.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Patients with paclitaxel-eluting stents (n=11), sirolimus-eluting stents (n=21), biolimus A9-eluting stents (n=28), zotarolimus-eluting stents (n=10), and bare-metal stents (n=13) were studied 10, 9, 9, 9, and 12 months after implantation, respectively. Endothelium-dependent coronary vasomotion was tested proximally and distally to the stent and at a reference vessel segment during atrial pacing at increasing heart rates by quantitative coronary angiography. Indexes of platelet-monocyte binding and other biomarkers were studied in a subgroup of 19 patients. The baseline characteristics and hemodynamics of the patients in the different stent groups were comparable. Significant differences were observed across the 5 stent groups, concerning the vasomotion of segments proximal (\n            <jats:italic>P<\/jats:italic>\n            =0.006) and distal (\n            <jats:italic>P<\/jats:italic>\n            =0.003) to the stent. Normal vasomotion (vasodilatation) was maintained in the biolimus A9-eluting stent, zotarolimus-eluting stent, and bare-metal stent groups, whereas vasoconstriction was observed in the sirolimus-eluting stent and paclitaxel-eluting stent groups. Platelet-monocyte binding in whole blood showed a significant inverse correlation with vasomotion in reference but not in segments adjacent to the stent (\n            <jats:italic>r<\/jats:italic>\n            =\u22120.57;\n            <jats:italic>P<\/jats:italic>\n            =0.01).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Paclitaxel-eluting stents and sirolimus-eluting stents seem to cause endothelial dysfunction of the implanted vessel, whereas biolimus A9-eluting stents and zotarolimus-eluting stents behave more closely to bare-metal stents, with preserved endothelial vasomotor response. Coronary vasoconstriction was not associated with detectable systemic endothelial activation.\n          <\/jats:p>","DOI":"10.1161\/circinterventions.108.797928","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T03:23:47Z","timestamp":1229484227000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Interference of Drug-Eluting Stents With Endothelium-Dependent Coronary Vasomotion"],"prefix":"10.1161","volume":"1","author":[{"given":"Michalis","family":"Hamilos","sequence":"first","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaydeep","family":"Sarma","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miodrag","family":"Ostojic","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cuisset","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Sarno","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narbeh","family":"Melikian","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyrios","family":"Ntalianis","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Muller","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branco","family":"Beleslin","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Sagic","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"De Bruyne","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Bartunek","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; and Institute for Cardiovascular Disease (D.S.), Dedinje, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Centre Aalst (M.H., J.S., T.C., G.S., N.M., A.N., O.M., E.B., B.D.E., J.B., W.W.), Belgium; the Department of Cardiology (M.O., B.B.), University Institute for Cardiovascular Diseases, Clinical Center of Serbia, Serbia; 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