{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:01:09Z","timestamp":1792404069808,"version":"4.4.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Percutaneous aortic valve replacement is a new emerging technology for interventional treatment of severe aortic valve stenosis in surgical high-risk patients. This study was intended to provide a summary of the development and current safety and efficacy status of the self-expanding CoreValve Revalving prosthesis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Method and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Between 2005 and 2008, we have enrolled 136 consecutive patients with percutaneous aortic valve replacement using the CoreValve prosthesis. In this prospective nonrandomized, single-center trial, we analyzed procedural outcome, complications and clinical status up to 1 year. First, second, and third generation of the CoreValve prosthesis were implanted in 10, 24, and 102 consecutive high-risk patients (logistic EuroScore: 23.1\ufffd15.0%) with severe symptomatic aortic valve stenosis. Mean transvalvular pressure gradient was 41.5\ufffd16.7 mm Hg. The procedural success rate increased from generation 1\/2 to 3 from 70.0%\/70.8% to 91.2% (\n            <jats:italic>P<\/jats:italic>\n            =0.003). The 30-day combined rate of death\/stroke\/myocardial infarction was 40.0%\/20.8%\/14.7% (\n            <jats:italic>P<\/jats:italic>\n            =0.11) for generation 1, 2, and 3, with no procedural death in generation 3. Pressure gradients improved significantly with a final mean gradient of 8.1\ufffd3.8 mm Hg. Overall functional status assessed by New York Heart Association class improved from 3.3\ufffd0.5 (pre) to 1.7\ufffd0.7 (post) (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and remained stable in the follow-up.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            In experienced hands, percutaneous aortic valve replacement with the CoreValve system for selected patients with severe aortic valve stenosis has a high acute success rate associated with a low periprocedural mortality\/stroke rate as well as remarkable clinical and hemodynamic improvements, which persist over time. Additional studies are now required to confirm these findings, particularly head-to-head comparisons with surgical valve replacement in different risk populations.\n          <\/jats:p>","DOI":"10.1161\/circinterventions.108.819839","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T03:23:47Z","timestamp":1229484227000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":276,"title":["Progress and Current Status of Percutaneous Aortic Valve Replacement: Results of Three Device Generations of the CoreValve Revalving System"],"prefix":"10.1161","volume":"1","author":[{"given":"Eberhard","family":"Grube","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Buellesfeld","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Mueller","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barthel","family":"Sauren","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernfried","family":"Zickmann","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Nair","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Beucher","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Felderhoff","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Iversen","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gerckens","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (E.G., L.B., U.G., R.M., D.N.), Cardiac Surgery (T.F., S.I.), and Anaesthesiology (B.S., B.Z.), HELIOS Heart Center Siegburg, Siegburg, 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