{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:12:45Z","timestamp":1782832365665,"version":"3.54.5"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Women are at a higher risk for bleeding\/vascular complications (VC) related to cardiovascular procedures. Although the overall incidence of percutaneous coronary intervention (PCI)-related bleeding\/VC has declined, the impact of this decline, specifically in women, is unknown.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We studied 13 653 female and 32 334 male consecutive cases, from 2002 to 2007, in the Northern New England PCI Registry. We sought to (1) compare absolute rates of bleeding\/VC in women and men over time, (2) define predictors of bleeding\/VC in women and men undergoing PCI, and (3) trend the impact of female gender in predicting bleeding\/VC over time. Bleeding\/VC was defined as any access-site vessel injury requiring surgical intervention or bleeding requiring transfusion. The overall risk of bleeding\/VC was significantly higher in women versus men (4.5\ufffd1.3% versus 1.6\ufffd0.5%;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.004). Over time, there was a significant (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) 50% decrease in absolute bleeding\/VC rates in both women and men. After adjustment for baseline differences, female gender remained a significant predictor of increased risk in 2007 (odds ratio, 2.6; 95% CI, 1.74 to 3.91). Independent predictors of increased risk of bleeding\/VC in women included older age, shock, renal failure, presentation with non-ST-elevation myocardial infraction and larger sheath sizes, whereas the use of fluoroscopy-guided access, closure devices, history of dyslipidemia or prior PCI, and use of bivalirudin were protective.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Women undergoing PCI have had a significant decline in bleeding\/VC rates during the last 6 years. Despite the improvement in procedural safety, female gender continues to be associated with a &gt;2-fold risk of bleeding\/VC compared with men.\n          <\/jats:p>","DOI":"10.1161\/circinterventions.109.860494","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T03:08:27Z","timestamp":1251860907000},"page":"423-429","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":139,"title":["Significantly Improved Vascular Complications Among Women Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"2","author":[{"given":"Bina","family":"Ahmed","sequence":"first","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winthrop D.","family":"Piper","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malenka","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"VerLee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Robb","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ryan","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Herne","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Phillips","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold L.","family":"Dauerman","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology (B.A., H.L.D.), University of Vermont College of Medicine, Burlington, Vt; Section of Cardiology (W.D.P., D.M., J.R.), Dartmouth-Hitchcock Medical Center, Lebanon, NH; Division of Cardiology (P.V.), Eastern Maine Medical Center, Bangor, Me; Division of Cardiology (T.R.), Maine Medical Center, Portland, Me; Catholic Medical Center (M.H.), Manchester, NH; and Central Maine Medical Center (W.P.), Lewiston, Me."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.027"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.040"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.028"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.612812"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn358"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00079-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01679-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.048"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.04.036"},{"key":"e_1_3_2_10_2","first-page":"247","year":"2004","unstructured":"Eggebrecht H, von BC, Naber C, Kroger K, Schmermund A, Wieneke H, Bartel T, Wortgen U, Baumgart D, Haude M, Erbel R. 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