{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:54:46Z","timestamp":1773251686913,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In the COREA-TAXUS trial (\u201cEffect of Celecoxib On REstenosis after coronary Angioplasty with a TAXUS stent\u201d), celecoxib reduced late luminal loss and adverse cardiac events at follow-up around 6 months. The objective of this study was to assess the long-term outcome of short-term adjunctive celecoxib treatment after paclitaxel-eluting stent implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This is a 2-year clinical follow-up of the COREA-TAXUS trial, an open-label randomized controlled study. A total 274 patients were randomized to receive or not receive celecoxib (400 mg before the intervention and 200 mg twice daily for 6 months after the procedure), and 271 underwent successful paclitaxel-eluting stent implantation. All patients were given aspirin (100 mg daily indefinitely) and clopidogrel (75 mg daily for at least 6 months). Among the 271 patients, 267 (98.5%) completed the 2-year clinical follow-up. From the previous follow-up to 2 years, there was no difference in the rate of adverse cardiac events between the celecoxib and control groups (1.6% versus 4.3%,\n              <jats:italic>P<\/jats:italic>\n              =0.27). Thus, at 2 years, the rate of adverse cardiac events was consistently lower in the celecoxib group (6.9% versus 19.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.002). A significant reduction in need for target lesion revascularization was observed (6.2% versus 18.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.003). The efficacy benefit in the celecoxib group was not undermined by an increased risk for cardiac death or myocardial infarction at 2 years (1.5% versus 1.4%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Six-month adjunctive celecoxib treatment after paclitaxel-eluting stent implantation was associated with durable long-term efficacy up to 2 years. However, the inconclusive evidence for the long-term safety of this treatment warrants caution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT 00292721.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.109.889881","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T02:45:06Z","timestamp":1274237106000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Long-Term Outcome of Adjunctive Celecoxib Treatment After Paclitaxel-Eluting Stent Implantation for the Complex Coronary Lesions"],"prefix":"10.1161","volume":"3","author":[{"given":"Jin-Wook","family":"Chung","sequence":"first","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Shik","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jae","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Seok","family":"Cho","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Jin","family":"Youn","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon-Kwon","family":"Koo","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Ho","family":"Chae","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Hee","family":"Oh","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Bae","family":"Park","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; Cardiovascular Center (Y.-S.C., T.-J.Y., I.-H.C., D.-J.C.), Seoul National University Bundang Hospital; and Molecular Medicine and Biopharmaceuticals Sciences (H.-S.K.), Seoul National University, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center (J.-W.C., H.-M.Y., K.-W.P., H.-Y.L., J.-S.P., H.-J.K., B.-K.K., B.-H.O., Y.-B.P., H.-S.K.), Seoul National University Hospital; 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