{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:20:46Z","timestamp":1785853246543,"version":"3.56.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The long-term natural history of acquired malapposition continues to be the subject of debate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Using volumetric intravascular ultrasound analyses, we evaluated serial (poststenting, 6-month, and 2-year follow-up) changes in drug-eluting stent\u2013treated vascular segments with acquired malapposition. External elastic membrane, stent, lumen, malapposition, and peristent plaque+media (P+M=external elastic membrane \u2212stent\u2212 malapposition) areas were measured; and volumes were calculated and divided by stent length (normalized volume). Among 250 lesions in which complete serial intravascular ultrasound data were available, stent malapposition was identified in 19 lesions (7.6%) at 6 months, and an additional 13 malapposition lesions were newly detected at 2 years (5.2%). Because no malapposition sites resolved, the malapposition rate at 2 years was 12.8%. Malapposition areas and volumes were correlated to the increases in external elastic membrane (positive remodeling) throughout the study period, from immediately after stenting to 6 months and from 6 months to 2 years, both in the group that developed malapposition at 6 months and in the group that developed malapposition at 2 years. Clinical follow-up beyond the 2 year intravascular ultrasound study was done in all patients. Overall, there were 2 cardiac deaths and 1 noncardiac death. Two patients presented with acute myocardial infarction associated with very late stent thrombosis (1 definite stent thrombosis, 1 probable stent thrombosis). Three patients underwent repeat revascularization owing to in-stent restenosis developed after the 2-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Expansive vascular remodeling may play a role in the development and dynamic progression of acquired drug-eluting stent malapposition, not only during the first 6 months after implantation but thereafter.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.109.916502","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T03:01:20Z","timestamp":1278471680000},"page":"335-340","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Late and Very Late Drug-Eluting Stent Malapposition"],"prefix":"10.1161","volume":"3","author":[{"given":"Soo-Jin","family":"Kang","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Hoon","family":"Han","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (S.-J.K., D.-W.P., S.-W.L., Y.H.K., C.W.L., K.-H.H., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea, and the Cardiovascular Research Foundation (G.S.M.), New York, 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