{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:55:54Z","timestamp":1772909754659,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>To expand the paucity of data on the efficacy of various drug-eluting stents in diabetic patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Type 2 diabetic patients treated in our institution from October 2005 to January 2007 presenting with of de novo lesions in native coronary arteries were randomly assigned to sirolimus-eluting stents (Cypher group; n=76); paclitaxel-eluting stents (Taxus group; n=75); and everolimus-eluting stents (Endeavor group; n=75). Poor metabolic control (HbA1c &gt;7% and low-density lipoprotein cholesterol &gt;100 mg\/dL) and microvascular complications (retinopathy and\/or nephropathy) were assessed. The primary end point was the 3-year composite of major adverse cardiac events (MACE), including death of any cause, myocardial infarction, and clinically driven target vessel revascularization. MACE-free survival was 86.8% in the Cypher group, 82.5% in the Taxus group, and 64.4% in the Endeavor group (\n              <jats:italic>P<\/jats:italic>\n              =0.006 by log-rank test). The post hoc comparisons showed no significant difference between Cypher versus Taxus groups (adjusted\n              <jats:italic>P<\/jats:italic>\n              =1.0) but a higher MACE rate in the Endeavor group versus both the Cypher group (adjusted\n              <jats:italic>P<\/jats:italic>\n              =0.012) and the Taxus group (adjusted\n              <jats:italic>P<\/jats:italic>\n              =0.075). Independent predictors of 3-year MACE at Cox analysis were treatment by Endeavor versus Cypher stent (2.35 [95% confidence interval, 1.07 to 5.41];\n              <jats:italic>P<\/jats:italic>\n              =0.030), multivessel disease (hazard ratio, 1.78 [95% confidence interval, 1.06 to 2.66];\n              <jats:italic>P<\/jats:italic>\n              =0.031), diabetic retinopathy (hazard ratio, 1.60; [95% confidence interval, 1.03 to 2.76];\n              <jats:italic>P<\/jats:italic>\n              =0.038), and poor metabolic control (hazard ratio, 1.60; [95% confidence interval, 1.02 to 2.52];\n              <jats:italic>P<\/jats:italic>\n              =0.048).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The present pilot study suggests that in diabetic patients, the Endeavor stent is associated with a higher 3-year MACE rate when compared with Cypher and Taxus stents.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.110.959924","type":"journal-article","created":{"date-parts":[[2011,3,2]],"date-time":"2011-03-02T08:22:17Z","timestamp":1299054137000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Novel Approaches for Preventing or Limiting Events in Diabetic Patients (Naples-Diabetes) Trial"],"prefix":"10.1161","volume":"4","author":[{"given":"Carlo","family":"Briguori","sequence":"first","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Airoldi","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Visconti","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Focaccio","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Golia","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Biondi-Zoccai","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. Condorelli), \u201cFederico II\u201d University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Ricciardelli","sequence":"additional","affiliation":[{"name":"From the Laboratory of Interventional Cardiology and Department of Cardiology (C.B., G.V., A.F., G. Caiazzo, B.G., B.R.), Clinica Mediterranea, Naples, Italy; Laboratory of Interventional Cardiology IRCCS Multimedica (F.A.), Milan, Italy; the Division of Cardiology (G.B.-Z.), University of Modena e Reggio Emilia, Modena, Italy; and Dipartimento di Biologia e Patologia Cellulare e Molecolare (G. 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