{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:33:03Z","timestamp":1791275583297,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The frequency, predictors, and consequences of stent thrombosis (ST) in patients with non\u2013ST-segment elevation acute coronary syndromes (NSTE-ACS) have been incompletely studied. We sought to investigate the incidence, predictors, and clinical implications of ST occurring within 1 year after percutaneous coronary intervention in patients with NSTE-ACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The Acute Catheterization and Urgent Intervention Triage StrategY (ACUITY) trial was a large-scale, prospective, randomized trial of antithrombotic regimens in patients with NSTE-ACS. The present analysis includes 7162 patients in whom stents were implanted. At 1 year, definite\/probable ST occurred in 146 patients (2.2%), including 94 definite and 52 probable events. There were 100 episodes (1.4%) of early ST (within the first 30 days) and 46 episodes (0.8%) of late ST (between 30 days and 1 year). The incidence of ST within 1 year was similar in patients treated with drug-eluting stents or bare metal stents (hazard ratio, 0.86; 95% confidence interval, 0.62\u20131.20;\n              <jats:italic>P<\/jats:italic>\n              =0.38) and was independent of procedural antithrombotic treatment. Patients with ST compared with those without ST had strikingly higher 1-year rates of cardiac mortality (32.4% versus 2.9%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), myocardial infarction (82.6% versus 7.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), and target vessel revascularization (79.6% versus 7.4%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Independent predictors of 1-year definite\/probable ST were insulin-treated diabetes mellitus, number of diseased vessels, and ST-segment deviation \u22651 mm.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Compared with elective stent implantation, ST occurs with increased frequency in the first year after stent implantation in patients with NSTE-ACS, especially within the first 30 days, and is associated with marked increases in cardiac mortality and adverse events. Insulin-treated diabetes, number of diseased vessels, and dynamic ST-segment changes were independent predictors of 1-year ST in NSTE-ACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00093158.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.111.963884","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:22:15Z","timestamp":1319588535000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Predictors and Implications of Stent Thrombosis in Non\u2013ST-Segment Elevation Acute Coronary Syndromes"],"prefix":"10.1161","volume":"4","author":[{"given":"Tullio","family":"Palmerini","sequence":"first","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Caixeta","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Fahy","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecaterina","family":"Cristea","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"From Istituto Cardiologia, Policlinico S Orsola, Bologna, Italy (T.P.); Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY (T.P., A.C., P.G., M.F., K.X., E.C., G.W.S.); Mount Sinai Medical Center and the Cardiovascular Research Foundation, New York, NY (G.D., R.M.); and Yale University School of Medicine, New Haven, CT (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.11.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.693739"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.600155"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60314-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.17.2126"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.079"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000127105.99982.21"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.04.003"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.092"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.762047"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.804203"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.04.036"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80005-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067193"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.5.608"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.61"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.09.014"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61484-7"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60441-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062006"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.051"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00452-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.666800"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl282"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072771.11429.83"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.01.011"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.031"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.011"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910496"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706482"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.111.963884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:19:32Z","timestamp":1715566772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.111.963884"}},"subtitle":["The ACUITY Trial"],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.111.963884"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.111.963884","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}