{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:24:21Z","timestamp":1763036661676},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the\n              <jats:italic>ABCB1<\/jats:italic>\n              gene. Prior studies suggested that a common and functional genetic variant (C3435T, rs1045642) within\n              <jats:italic>ABCB1<\/jats:italic>\n              influences clopidogrel treatment efficacy; however, existing data are highly inconsistent, because other studies failed to replicate this postulated association. Thus, the aim of this study was to assess the association of\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T genotypes with the antiplatelet efficacy of clopidogrel and the risk of stent thrombosis (ST) in large cohorts of clopidogrel-treated patients undergoing percutaneous coronary intervention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              DNA samples from 1524 clopidogrel-treated patients undergoing percutaneous coronary intervention were genotyped for\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T, and ADP-induced platelet aggregation was assessed in whole blood on a Multiplate analyzer. The clinical impact of the genetic variant was investigated by comparison of genotype frequencies in a registry of 66 cases with definite drug-eluting stent ST versus an ST-free control cohort (n=1408). Platelet aggregation values were similar across\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T genotypes (\n              <jats:italic>P<\/jats:italic>\n              =0.73). No significant influence of\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T genotypes on the occurrence of ST was found when ST case subjects were compared with control subjects (\n              <jats:italic>P<\/jats:italic>\n              =0.89).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T genotypes did not influence the antiplatelet response to clopidogrel or the risk of ST in clopidogrel-treated patients undergoing percutaneous coronary intervention. Routine genotyping of\n              <jats:italic>ABCB1<\/jats:italic>\n              C3435T polymorphisms should not be recommended for risk stratification in clopidogrel-treated patients undergoing percutaneous coronary intervention who are similar to those evaluated in the present study.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.111.965400","type":"journal-article","created":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T06:14:07Z","timestamp":1328076847000},"page":"82-88","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["No Association of\n            <i>ABCB1<\/i>\n            C3435T Genotype With Clopidogrel Response or Risk of Stent Thrombosis in Patients Undergoing Coronary Stenting"],"prefix":"10.1161","volume":"5","author":[{"given":"Juliane","family":"Jaitner","sequence":"first","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Morath","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Byrne","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegmund","family":"Braun","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gebhard","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabell","family":"Bernlochner","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Schulz","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julinda","family":"Mehilli","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen (J.J., T.M., R.A.B., S.B., D.G., I.B., S.S., J.M., A.S., W.K., A.K., D.S.), Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Sch\u00f6mig","sequence":"additional","affiliation":[{"name":"From the Deutsches Herzzentrum M\u00fcnchen and 1. 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