{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:18:33Z","timestamp":1791429513504,"version":"4.3.3"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      We randomly assigned 60 patients with ST-elevation\u2013MI to receive an intravenous bolus of DFO (500 mg) immediately before PPCI followed by a 12-hour infusion (50 mg\/kg of body weight) (n=28) or normal saline bolus and infusion (placebo group, n=32). MI size was measured by contrast-enhanced cardiac MRI (CMRI; day 3\u00b11), creatine kinase and troponin I area-under-the-curve, and severity of wall motion abnormality on echocardiography. Clinical follow-up including repeat CMRI and echocardiography were performed at 3 months (100\u00b117 days). Oxidative stress was assessed by plasma F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane levels. DFO and placebo groups were well balanced with respect to baseline characteristics, symptom- and door-to-balloon times, pre-PPCI coronary patency, and infarct-related artery location. Serum iron levels were decreased with DFO treatment after PPCI compared with placebo (3.0\u00b12.5 versus 12.6\u00b15.5 \u03bcmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), which persisted until the end of the infusion. In DFO-treated patients, there was a significant reduction in plasma F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane levels immediately after PPCI (2878\u00b11461 versus 2213\u00b1579 pmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      =0.04). However, there was no difference in CMRI-determined infarct size (DFO, 17.4\u00b110.8%, versus placebo, 18.6\u00b110.2%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.73), myocardial salvage index at 3 days or at 3 months, or the area-under-the-curve for creatine kinase or troponin I.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Adjunctive DFO treatment after the onset of ischemia and continued periprocedurally ameliorates oxidative stress without limiting infarct size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.anzctr.org.au\/\">http:\/\/www.anzctr.org.au\/<\/jats:ext-link>\n                      . Unique identifier: ACTRN12608000308392.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.111.966226","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T20:47:59Z","timestamp":1334090879000},"page":"270-278","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Effect of Iron Chelation on Myocardial Infarct Size and Oxidative Stress in ST-Elevation\u2013Myocardial Infarction"],"prefix":"10.1161","volume":"5","author":[{"given":"William","family":"Chan","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andris H.","family":"Ellims","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lefkovits","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiew","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn A.","family":"Kingwell","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaina","family":"Natoli","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Croft","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Mori","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Kaye","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Dart","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Duffy","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Australia (W.C., A.J.T., A.H.E., L.L., C.W., D.M.K., A.M.D., S.J.D.); Baker IDI Heart and Diabetes Institute, Melbourne, Australia (W.C., A.J.T., A.H.E., C.W., B.A.K., A.N., D.M.K., A.M.D., S.J.D.); School of Medicine and Pharmacology, University of Western Australia, Perth, Australia (K.D.C., T.M.); and the Department of Medicine, Monash University, Melbourne, Australia (A.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90700-B"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(83)90260-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113621"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.5.1404"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2511"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80857-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111050"},{"key":"e_1_3_3_9_2","first-page":"H1901","article-title":"Iron-mediated radical reactions upon reperfusion contribute to myocardial \u201cstunning.\u201d","volume":"259","author":"Bolli R","year":"1990","unstructured":"Bolli R, Patel BS, Jeroudi MO, Li XY, Triana JF, Lai EK, McCay PB. 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