{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:17:00Z","timestamp":1787642220131,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In patients with ST-segment elevation myocardial infarction undergoing thrombolytic therapy, the degree of ST-segment resolution (STR) correlates with long-term cardiovascular mortality. The long-term predictive value of STR after primary percutaneous coronary intervention (PCI) is less well understood. We sought to determine the long-term prognostic value of STR after primary PCI in ST-segment\u2013elevation myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In a formal substudy from the Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial, 2484 patients with ST-segment\u2013elevation myocardial infarction undergoing primary PCI with interpretable baseline and 60-minute post-PCI electrocardiograms had at least 1 mm of baseline ST-segment elevation in \u22652 contiguous leads. Patients were categorized by the degree of STR at 60 minutes: (1) complete (&gt;70%); (2) partial (30%\u201370%); and (3) absent (&lt;30%). Absent, incomplete, and complete STR were achieved in 514 (20.7%), 712 (28.7%), and 1258 (50.5%) patients, respectively. STR &lt;30% was associated with a greater likelihood of hypertension, diabetes mellitus, longer symptom onset to balloon time, lower left ventricular ejection fraction, and final thrombolysis in myocardial infarction flow &lt;3. At 3 years, patients with STR&lt;30% experienced a higher rate of major adverse cardiovascular events (death, reinfarction, ischemia-driven target vessel revascularization or stroke; 29.9% versus 20.1% versus 19.6%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), ischemia-driven target vessel revascularization (20.4% versus 14.0% versus 11.7%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and mortality (8.4% versus 5.0% versus 5.6%;\n              <jats:italic>P<\/jats:italic>\n              =0.03) than those with partial and complete STR, respectively. By multivariable analysis, STR&lt;30% was an independent predictor of 3-year major adverse cardiovascular events (hazard ratio, 1.58; 95% confidence interval, 1.24\u20132.00;\n              <jats:italic>P<\/jats:italic>\n              =0.0002) and 3-year ischemia-driven target vessel revascularization (hazard ratio, 1.87; 95% confidence interval, 1.41\u20132.48;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this large international study, absent STR 60 minutes after primary PCI was present in \u22481 in 5 patients with ST-segment\u2013elevation myocardial infarction and was a significant independent predictor of major adverse cardiovascular events and target vessel revascularization at 3 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00433966\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.112.000142","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T05:42:57Z","timestamp":1367991777000},"page":"216-223","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Relationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"6","author":[{"given":"Michael E.","family":"Farkouh","sequence":"first","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Reiffel","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Dressler","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Nikolsky","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Parise","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecatarina","family":"Cristea","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Baran","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Dizon","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques P.","family":"Merab","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J.","family":"Lansky","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"From the Peter Munk Cardias Centre and Heart and Stroke Lewar Centre, Toronto, ON (M.E.F.); Mount Sinai School of Medicine, New York, NY (M.E.F., R.M.); Cardiovascular Research Foundation, New York, NY (M.E.F., J.R., O.D., E.N., H.P., E.C., R.M., G.W.S.); Columbia University Medical Center, New York, NY (J.R., J.D., J.P.M., G.W.S.); Newark Beth Israel Medical Center, Newark, NJ (D.A.B.); and Yale School of Medicine, New Haven, CT (A.J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022700"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.191098"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.12.034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.084"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708191"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810116"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.02.031"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07120-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00466-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.15.1972"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.053"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192663"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn416"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.767772"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.10.037"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60764-2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.011"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.112.000142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:53:03Z","timestamp":1715568783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.112.000142"}},"subtitle":["The HORIZONS-AMI ECG Substudy Report"],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.112.000142"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.112.000142","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"2012-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}