{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:56:59Z","timestamp":1791219419423,"version":"4.1.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Chronic thromboembolic pulmonary hypertension leads to pulmonary hypertension and right-sided heart failure. The purpose of this study was to investigate the efficacy of percutaneous transluminal pulmonary angioplasty (PTPA) for the treatment of chronic thromboembolic pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      Twenty-nine patients with chronic thromboembolic pulmonary hypertension underwent PTPA. One patient had a wiring perforation as a complication of PTPA and died 2 days after the procedure. In the remaining 28 patients, PTPA did not produce immediate hemodynamic improvement at the time of the procedure. However, after follow-up (6.0 \u00b1 6.9 months), New York Heart Association functional classifications and levels of plasma B-type natriuretic peptide significantly improved (both\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Hemodynamic parameters also significantly improved (mean pulmonary arterial pressure, 45.3 \u00b1 9.8 versus 31.8 \u00b1 10.0 mm Hg; cardiac output, 3.6 \u00b1 1.2 versus 4.6 \u00b1 1.7 L\/min, baseline versus follow-up, respectively; both\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Twenty-seven of 51 procedures in total (53%), and 19 of 28 first procedures (68%), had reperfusion pulmonary edema as the chief complication. Patients with severe clinical signs and\/or severe hemodynamics at baseline had a high risk of reperfusion pulmonary edema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>PTPA improved subjective symptoms and objective variables, including pulmonary hemodynamics. PTPA may be a promising therapeutic strategy for the treatment of chronic thromboembolic pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.umin.ac.jp\">http:\/\/www.umin.ac.jp<\/jats:ext-link>\n                      . Unique identifier: UMIN000001572.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.112.971390","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T04:09:05Z","timestamp":1352261345000},"page":"756-762","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":332,"title":["Percutaneous Transluminal Pulmonary Angioplasty for the Treatment of Chronic Thromboembolic Pulmonary Hypertension"],"prefix":"10.1161","volume":"5","author":[{"given":"Masaharu","family":"Kataoka","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Inami","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Shimura","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Abe","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomi","family":"Ando","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Yoshino","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Satoh","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Kyorin University School of Medicine and Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (M.K., K.H.); Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Tokyo, Japan (T.I., N.S., H.I., H.Y., T.S.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (Y.T., K.F.); Center for Clinical Research, Keio University School of Medicine, Tokyo, Japan (T.A.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910203"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1854CI"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.07.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00007309"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e328311f254"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.661041"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.053603"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.602565"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00079704"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-010-0156-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.015008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.024"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.12.056"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.865881"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.016"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.6.1249"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.10"},{"key":"e_1_3_3_20_2","first-page":"274","article-title":"Technique and outcomes of pulmonary endarterectomy surgery.","volume":"14","author":"Thistlethwaite PA","year":"2008","unstructured":"Thistlethwaite PA, Kaneko K, Madani MM, Jamieson SW. 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