{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:47:43Z","timestamp":1777985263782,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Transcatheter pulmonary valve implantation using the Melody valve has emerged as an important therapy for the treatment of postoperative right ventricular outflow tract dysfunction. Melody-in-bioprosthetic valves (BPV) is currently considered an off-label indication. We review the combined experience with transcatheter pulmonary valve implantation within BPVs from 8 centers in the United States and discuss technical aspects of the Melody-in-BPV procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      A total of 104 patients underwent Melody-in-BPV in the pulmonary position at 8 US centers from April 2007 to January 2012. Ten different types of BPVs were intervened on, with Melody valve implantation at the intended site in all patients. Following Melody valve implant, the peak right ventricle-to-pulmonary artery gradient decreased from 38.7\u00b116.3 to 10.9\u00b16.7 mm Hg (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and the right ventricular systolic pressure fell from 71.6\u00b121.7 to 46.7\u00b115.9 mm Hg (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). There was no serious procedural morbidity, and no deaths related to the catheterization or implant. At a median follow-up of 12 months (1\u201346 months), no patients had more than mild regurgitation, and 4 had a mean right ventricular outflow tract gradient \u226530 mm Hg. During follow-up, there were 2 stent fractures, 3 cases of endocarditis (2 managed with surgical explant), and 2 deaths that were unrelated to the Melody valve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Transcatheter pulmonary valve implantation using the Melody valve within BPVs can be accomplished with a high rate of success, low procedure-related morbidity and mortality, and excellent short-term results. The findings of this preliminary multicenter experience suggest that the Melody valve is an effective transcatheter treatment option for failed BPVs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.112.972216","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T11:00:32Z","timestamp":1354705232000},"page":"862-870","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["Melody Valve Implant Within Failed Bioprosthetic Valves in the Pulmonary Position"],"prefix":"10.1161","volume":"5","author":[{"given":"Matthew J.","family":"Gillespie","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Rome","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Levi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Rhodes","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Cheatham","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Hellenbrand","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Vincent","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan M.","family":"Zahn","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doff B.","family":"McElhinney","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Children\u2019s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (M.J.G., J.J.R.); Division of Pediatric Cardiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA (D.S.L., R.J.W.); Division of Cardiology, Duke University School of Medicine, Durham, NC (J.F.R.); Division of Cardiology, Nationwide Children\u2019s Hospital, Ohio State University School of Medicine, Columbus, OH (J.P.C.);..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02844-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.523266"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.034"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.735779"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq520"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.061"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq056"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00930-X"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.009"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.01.044"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.110.957555"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.05.007"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.016"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I11A202"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22618"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.023"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.924613"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.060"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.921692"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.674259"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.111.965616"},{"key":"e_1_3_2_24_2","first-page":"110","article-title":"[Non-surgical, transcatheter pulmonary valve implantation - first experience].","volume":"67","author":"Demkow M","year":"2009","unstructured":"Demkow M, Ruzy\u0142\u0142o W, W\u0142odarska EK, Kowalski M, Mi\u015bko J, Spiewak M, Siudalska H, Wolski P. 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