{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:27:02Z","timestamp":1790774822138,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Emerging drug-eluting stent technologies are evolving toward the elimination of polymeric component used as the method for modulating drug delivery. Although this technological approach seems to be biologically appealing, the impact of durable polymers and metallic stent surfaces on vascular healing remains unclear. In the present study, we aimed to compare the independent effect of a durable polymer and a metallic stent surface on thrombogenicity and endothelial cell coverage using different in vitro and in vivo experimental models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      Platinum chromium (PtCr) and polyvinylidene fluoride-co-hexafluoropropene (PVDF-HFP)\u2013coated surfaces were evaluated in this study. Thrombogenicity was assessed by exposing all surfaces to human blood under shear flow conditions. The inflammatory potential of the material was evaluated by measuring cytokine release from THP-1 cells exposed to all surfaces for 24 hours. Endothelial cell coverage was evaluated by detection of CD31 after the stents were exposed to human coronary artery endothelial cells for \u226414 days. Platelet adhesion (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and activation (\n                      <jats:italic>P<\/jats:italic>\n                      =0.03) on PVDF-HFP were greater than on PtCr. In vivo, PVDF-HFP revealed more neointimal area (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and residual parastrut fibrin (\n                      <jats:italic>P<\/jats:italic>\n                      =0.01) at 30 days compared with PtCr. PtCr displayed higher endothelialization rates and higher vascular endothelial-cadherin expression at 7 and 14 days (\n                      <jats:italic>P<\/jats:italic>\n                      =0.02) compared with PVDF-HFP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Thrombogenicity and vascular healing differ among metallic and polymeric stent surfaces. PVDF-HFP exhibits higher degrees of platelet activation\u2013adhesion and thrombus accumulation in vivo compared with PtCr. PtCr displayed higher degrees of endothelial surface coverage compared with PVDF-HFP surfaces.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.113.000120","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T03:40:51Z","timestamp":1375242051000},"page":"370-377","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Impact of Stent Surface on Thrombogenicity and Vascular Healing"],"prefix":"10.1161","volume":"6","author":[{"given":"Michael J.","family":"Eppihimer","sequence":"first","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Sushkova","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Grimsby","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Efimova","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Kai","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Larson","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Forsyth","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Huibregtse","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Dawkins","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); Research and Development, Boston Scientific Corporation, Maple Grove, MN (W.K., S.L., B.F.); Clinical, Boston Scientific Corporation, Marlboro, MA (K.D.D.); Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada (G.J.W.); and Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, Orangeburg, NY (J.F.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Granada","sequence":"additional","affiliation":[{"name":"From the Preclinical, Boston Scientific Corporation, Natick, MA (M.J.E., N.S., J.L.G., N.E., B.A.H.); 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