{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:32:32Z","timestamp":1757457152475},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Background\u2014<\/jats:title>\n Diastolic fractional flow reserve (dFFR) has been shown to be highly sensitive for detection of inducible myocardial ischemia. However, its reliance on measurement of left-ventricular pressure for zero-flow pressure correction, as well as manual extraction of the diastolic interval, has been its major limitation. Given previous reports of minimal zero-flow pressure at end-diastole, we compared instantaneous ECG-gated end-diastolic FFR with conventional full-cardiac cycle FFR and other diastolic indices in the porcine model.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results\u2014<\/jats:title>\n \n Measurements of FFR in the left anterior descending and left circumflex arteries were performed in an open-chest swine model with an external occluder device on the coronary artery used to produce varying degrees of epicardial stenosis. An ultrasound flow-probe that was placed proximal to the occluder measured absolute blood flow in ml\/min, and it was used as a gold standard for FFR measurement. A total of 17 measurements at maximal hyperemia were acquired in 5 animals. Correlation coefficient between conventional mean hyperemic FFR with pressure-wire and directly measured FFR with flow-probe was 0.876 (standard error estimate=0.069;\n P<\/jats:italic>\n <0.0001). The hyperemic end-diastolic FFR with pressure-wire correlated better with FFR measured directly with flow-probe (\n r<\/jats:italic>\n =0.941, standard error estimate=0.050;\n P<\/jats:italic>\n <0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n Instantaneous hyperemic ECG-gated FFR acquired at end-diastole, as compared with conventional full-cardiac cycle FFR, has an improved correlation with FFR measured directly with ultrasound flow-probe.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circinterventions.113.000327","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T05:47:52Z","timestamp":1391579272000},"page":"28-34","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["End-Diastolic Fractional Flow Reserve"],"prefix":"10.1161","volume":"7","author":[{"given":"David A.","family":"Chalyan","sequence":"first","affiliation":[{"name":"From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA (S.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA (S.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeho","family":"Takarada","sequence":"additional","affiliation":[{"name":"From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA (S.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabee","family":"Molloi","sequence":"additional","affiliation":[{"name":"From the Department of Radiological Sciences, University of California-Irvine, Irvine, CA (D.A.C., Z.Z., S.M.); Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA (D.A.C.); Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China (Z.Z.); Division of Cardiology, University of California-Irvine, Orange, CA (S.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.177276"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.062"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.4.1354"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342604"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.157"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.19.2365"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00588-6"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.3.485"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/20.12.922"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.2.79"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.587196"},{"key":"e_1_3_4_15_2","first-page":"761","article-title":"Coronary flow is not that simple!","volume":"95","author":"Spaan JA","year":"2009","unstructured":"Spaan JA. Coronary flow is not that simple!Heart. 2009;95:761\u2013762.","journal-title":"Heart"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.3.1013"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.111.965707"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.035"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.113.000327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:17:35Z","timestamp":1715566655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.113.000327"}},"subtitle":["Comparison With Conventional Full-Cardiac Cycle Fractional Flow Reserve"],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.113.000327"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.113.000327","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2013-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}